Journal of Neuroscience
Articles in this Issue
CaMKII-Mediated Phase Separation as a Driver of Synaptic Maturation
Synaptic maturation coordinates structural spine remodeling with the nanoscale organization of neurotransmitter receptors. While Ca 2+ /calmodulin-dependent pro...
My Fifty Years Thinking about Emotional Consciousness in the Brain
This piece provides an overview of my fifty-year career as a neuroscientist. I spent much of this time trying to understand what emotions are and how they relate to human behavior and consciousness. I...
Erratum: Lee et al., “Single-Cell-Resolution Fate Mapping Reveals Embryonic Venous Origins of Fenestrated Hindbrain Choroid Plexus Vasculature”
Mapping the Heart–Brain Continuum beyond Heart Failure: Why Neurology Matters
To investigate whether cardiac dysfunction predicts further gray matter (GM) microstructural integrity and whether this integrity mediates the association with cognitive performance, we conducted a pr...
Decoding the Neural Stages from Action and Object Recognition to Mentalizing
Higher-level action interpretation, such as inferring underlying intentions and predicting future actions, requires the integration of conceptual action information (e.g., “opening”) with semantic kno...
Proactive Visual and Motor Prioritization Differentially Scale with Cue Reliability
Environmental cues enable the brain to anticipate and prepare for upcoming behavior, such as by selectively prioritizing relevant visual representations and associated action plans in working memory i...
The Extended Language Network: Language-Responsive Brain Areas Whose Contributions to Language Remain To Be Discovered
Although language neuroscience has largely focused on “core” left frontal and temporal brain areas and their right-hemisphere homotopes, numerous other areas—cortical and subcortical—have been implica...
Speakers with Cerebellar Ataxia Do Not Adapt Speech Segment Durations in Response to Durationally Altered Auditory Feedback
Sensorimotor adaptation (motor learning) is crucial to maintain movement accuracy. This is particularly true for temporal control, as duration and initiation timing are perceived only after the moveme...
The Precision of Hippocampal Representations Predicts Incremental Value Learning across the Adult Lifespan
Correctly assigning value to different options and leveraging this information to guide choice is a cornerstone of adaptive decision-making. Reinforcement learning (RL) has provided a computational fr...
Cortical and Thalamic Afferent Connectomes Distinguish ACC Subregions of the Macaque Brain
In humans and nonhuman primates, the anterior cingulate cortex (ACC) is an interface between “interoceptive” and “exteroceptive” domains. The ACC contains discrete subdivisions that are distinct in cy...
Trans-dimerization of Amyloid Precursor Protein Family Members Induces Pre- and Postsynaptic Differentiation through Distinct Signaling Pathways
The amyloid precursor protein (APP), a key factor in Alzheimer's disease (AD) pathology, and its two mammalian homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2), are considered as me...
Quantifying Changes in Pain Sensitivity Using Reproducible Transcutaneous Optogenetic Stimulation in Behaving Mice
Optogenetics provides an unprecedented opportunity to delineate how different somatosensory afferents contribute to sensation, including pain. Afferents expressing channelrhodopsin-2 (ChR2) can be sel...
Unilateral Striatal Deep Brain Stimulation Improves Cognitive Control
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VCVS) can treat obsessive-compulsive disorder (OCD) and other psychiatric conditions. Yet, optimizing its clinical efficacy is a m...