Journal of Neuroscience
Articles in this Issue
A Distinct Circuit for Biasing Visual Perceptual Decisions and Modulating Superior Colliculus Activity through the Mouse Posterior Striatum
The basal ganglia play a key role in visual perceptual decisions. Despite being the primary target in the basal ganglia for inputs from the visual cortex, the posterior striatum's (PS) involvement in...
The Ventral Attention Network Mediates Attentional Reorienting to Cross-Modal Expectancy Violations: Evidence from EEG and fMRI
Our daily interactions with the world are shaped by sensory expectations informed by context and prior experiences, which in turn influence how we allocate our attention. Prominent predictive coding m...
Alzheimer’s Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory
Aging is accompanied by the disruption of multiple neural systems including alteration in dopamine neurotransmission as well as through the accumulation of neuropathology. Despite broad appreciation t...
The Fronto-Temporal Cortex Has Increased Subcortical Connectivity In Utero and Plasticity in Adulthood
The adult cerebral cortex is a heterogeneous structure with prominent functional differences between regions. However, less is known about how different regions acquire and maintain their functionalit...
Molecular Signatures of Id2- and Ascl4-Induced Wiring of Adult Hippocampal Neurons
While circuit formation is generally thought to be absent in the adult brain, there is evidence that the adult brain retains a considerable capacity for neuronal wiring. Among other findings, molecula...
Amelioration of Symptomatic Alzheimer’s Disease after Selective Impairment of p75 <sup>NTR</sup> Function in Adult Forebrain Excitatory Neurons
The p75 neurotrophin receptor (p75 NTR ) contributes to the development of Alzheimer’s disease (AD) pathology by enhancing amyloid precursor protein (APP) cleav...
Dissociating Contributions of Theta and Alpha Oscillations from Aperiodic Neural Activity in Human Visual Working Memory
While visual working memory (WM) is strongly associated with reductions in occipitoparietal alpha (8–12 Hz) power, the role of frontal midline theta (4–7 Hz) power is less clear, with both increases a...
Alpha and Beta Corticomotor Phase Dynamics Shape Visuomotor Control on a Single-Trial Basis
A central question in sensorimotor neuroscience is how sensory inputs are mapped onto motor outputs to enable swift and accurate responses, even in the face of unexpected environmental changes. Here,...
Entorhinal Cortex Signals Dimensions of Past Experience That Can Be Generalized in a Novel Environment
No two situations are identical. They can be similar in some aspects but different in others. This poses a key challenge when attempting to generalize our experience from one situation to another. How...
In Vivo Expression of an SCA27A-Linked <i>FGF14</i> Mutation Results in Haploinsufficiency and Impaired Firing of Cerebellar Purkinje Neurons
Autosomal dominant mutations in FGF14 , which encodes intracellular fibroblast growth factor 14 (iFGF14), underlie spinocerebellar ataxia type 27A (SCA27A), a d...
Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron
In addition to providing outputs from the cerebellar cortex, Purkinje cell (PC) axon collaterals target other PCs, molecular layer interneurons (MLIs), and Purkinje layer interneurons (PLIs). It was a...
Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss
Single cell transcriptomics supports both cell-specific characterization and the identification of responses to changes in neural activity. Unilateral whisker denervation in adult male and female mice...
Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex
The binocular circuitry in mammals (e.g., mice, cats, and primates) integrates two distinct visual cortical circuitries—the contralateral and ipsilateral eye circuitries—into a cohesive functional sys...
Spatial Filters—In Search of the Virtual Electrode
A spatial filter combines signals from multiple sensors to create a virtual channel that emphasizes specific brain activity while reducing interference. Spatial...