Journal of Neuroscience
Articles in this Issue
The Role of Social Familiarity in the Transmission of Aggression
Minimal Mimics and Maps of Natural Light for Mammals
Light drives processes that include perception and the regulation of circadian rhythms, sleep, metabolism, and development. These processes are initiated by photopigment molecules, each preferentially...
Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training
Drug addiction is an acquired motivational-behavioral state that begins with drug taking, which is composed of a series of phases, including initial acquisition, stabilization, habituation, and mainte...
Neural Measures of Human Decision-Making Track Evidence Accumulation in Learned Space
Neural decision-making flexibly integrates evidence across sensory, mnemonic, and semantic domains. Yet prior demonstrations have focused on evidence that is either directly available in stimuli, retr...
Temporal Requirement for Stearoyl-CoA desaturase-1 in Oligodendrocyte Development But Not Myelin Maintenance
Stearoyl-CoA desaturase 1 ( Scd1 ) is a rate-limiting enzyme in monounsaturated fatty acid synthesis, which is crucial for membrane biosynthesis. Here we show a...
Attention to Pseudotone Melodies Enhances Cortical But Not Brainstem Responses in Humans
Auditory selective attention, the ability to focus on specific sounds while ignoring competitors, enables communication in complex soundscapes. Though attention clearly modulates cortical responses to...
Melanopsin's Phototransduction and Spiking Response Are Evident in the Photoreceptor-Directed Multifocal Electroretinogram
Existing methods of measuring melanopsin's functional response in humans can only return a measure of a postcortical interpretation of the intrinsic photoresponse. There is physiological ex vivo evide...
Testing the Role of Temporal Attention in Speech: Pretarget Alpha Predicts Memory Encoding Rather Than Effects of Linguistic Focus
The rapid, continuous flow of speech often places strong demands on attention. Listeners are thought to meet these demands by using linguistic focus cues to predict when important information will occ...
Intrinsic Diversity in Odor-Evoked Calcium Rises across <i>Drosophila</i> Olfactory Neurons
Across species, olfactory receptor neurons (ORNs) exhibit stimulus-driven changes in gene expression, with calcium as a key activity signal. However, it remains unclear whether neuronal activity eleva...
The Role of Inhibitory Neurons in Deviance Sound Detection in Regular and Random Statistical Contexts
Detecting statistical regularities in sound and responding to violations of these patterns, termed deviance detection, is a core function of the auditory system. In the human brain, studies have shown...
Longevity Factor Klotho and Resistance to Cognitive Deficits in Individuals with Parkinson’s Disease and in an α-Synuclein Mouse Model
Aging is the primary risk factor for Parkinson's disease (PD), and PD-related cognitive impairment remains a major unmet biomedical challenge. Klotho, a pleiotropic protein, extends lifespan and enhan...
Cochlear Dispersion Shapes Processing of Frequency Sweeps
The acoustic environment is often a superposition of competing sounds that, through interactions within the auditory system, can mask or reduce the audibility of target signals. While masking by stati...
Improving Emotion Control in Social Anxiety by Targeting Rhythmic Brain Circuits
Social avoidance is a hallmark of social anxiety disorder. Difficulties in controlling avoidance behavior are the core maintaining factor of this impairing condition, hampering the efficacy of existin...