Journal of Neuroscience
Articles in this Issue
The Anterior BNST Is Required for Novelty-Driven Social Interaction
Social novelty preference—the tendency to interact more with unfamiliar than familiar conspecifics—is conserved across species and disrupted in disorders such as autism spectrum disorder, schizophreni...
Predictive Distractor Processing Relies on Integrated Proactive and Reactive Attentional Mechanisms
Visual attention is shaped by statistical regularities in the environment, with spatially predictable distractors being proactively suppressed. The neural mechanisms underpinning this suppression rema...
Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging
How aging affects brain–body connections can be investigated through changes in the coupling between functional magnetic resonance imaging (fMRI) signals and bodily autonomic processes across the adul...
Kv4.2 <sup>V404M</sup> Mutation Induces Epileptiform Activity and Multiple Behavioral Abnormalities in Heterozygous Knock-in Mice
The KCND2 gene encodes the Kv4.2 voltage-gated potassium channel alpha subunit that underlies the somatodendritic subthreshold A-type current (I...
Rostral Ventromedial Medulla (RVM) Projects to the Lateral Hypothalamic Area (LHA) to Drive Aversion and Anxiety
Neurons in the lateral hypothalamic area (LHA) are critical drivers of behavioral and physiological responses to acute and chronic stress. However, the roles of the specific presynaptic inputs to the...
Localization and Functional Characterization of MDGA1 in Mouse Hippocampus
Neuron-to-neuron communication occurs mainly at chemical synapses. A network of synaptic organizer molecules orchestrates synapse formation, remodeling, and plasticity. The GPI-anchored MAM domain-con...
Cortical Somatostatin Innervation Follows a Unique Experience-Independent Developmental Trajectory
Despite the critical role of inhibition in regulating developmental plasticity, there are significant gaps in our understanding of inhibitory synapse development, particularly for the vast majority of...
Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer’s Disease
Executive dysfunction can precede the accumulation of canonical neuropathological markers and severe dementia in Alzheimer’s disease (AD) patients often characterized by memory changes. Deficits in ex...
Preparatory Attention to Visual Features Spreads Globally
Attention to visual features facilitates neural responses to task-relevant stimuli and also to task-irrelevant stimuli at other locations that share the attended features. This is assumed to enable gu...
Dopamine Responses in Medial Frontal Cortex Are More Consistent with a Generalized Arousal Signal Than Signed Reward Prediction Errors
The past two decades have seen increased interest in the function of dopamine (DA) by virtue of its role in generating Reward-Prediction Errors (RPEs) in the service of Reinforcement Learning. From th...
Reduced Post-Activation Depression in Humans with Spinal Cord Injury Is Not Related to Stretch Reflex Hyperexcitability
Post-activation depression of spinal reflexes is reduced following central motor lesions, including spinal cord injury (SCI), and has long been proposed to contribute to signs and symptoms associated...
Prenatal Stress and Prenatal Alcohol Alter the Adult Dopamine System and Alcohol Consumption: Dopamine Drives Drinking Behavior in a Prospective 20-Year Longitudinal Experiment with Rhesus Macaques
Given the prevalence of alcohol use and stress during pregnancy, we examined the effects in offspring of prenatal alcohol and stress on the dopamine system and drinking behavior in a primate model. In...