Journal of Neuroscience
Articles in this Issue
A New Molecular Mechanism for the Late-Onset Alzheimer's Disease Risk Gene CD2AP
Smell the Label: Odors Influence Label Perception and Their Neural Processing
Providing nutrition or health labels on product packaging can be an effective strategy to promote a conscious and healthier diet. However, such labels also have the potential to be counterproductive b...
Detection of Individual Differences Encoded in Sequential Variations of Elements in Zebra Finch Songs
Zebra finches sing individually unique songs and recognize conspecific songs and individual identities in songs. Their songs comprise several syllables/elements that share acoustic features within the...
Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons
Alpha-synuclein (αsyn) is the key pathogenic protein implicated in synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In these diseases, αsyn is thought to sprea...
A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep
Understanding the intricate mechanisms underlying slow-wave sleep (SWS) is crucial for deciphering the brain's role in memory consolidation and cognitive functions. It is well established that cortica...
Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study
A growing body of evidence suggests that the link between the cardiac autonomic nervous system (ANS) and the central nervous system (CNS) is crucial to the onset and development of major depressive di...
Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions
Emotionally arousing events are typically vividly remembered, which is generally adaptive but may contribute to mental disorders such as post-traumatic stress disorder. Previous research on emotional...
Neurophysiology of Perceptual Decision-Making and Its Alterations in Attention-Deficit Hyperactivity Disorder
Despite the prevalence of attention-deficit hyperactivity disorder (ADHD), efforts to develop a detailed understanding of the neuropsychology of this neurodevelopmental condition are complicated by th...
The Effect of Microsaccades in the Primary Visual Cortex: Increased Synchronization in the Fovea during a Two-Phase Response Modulation
Our eyes are never still. Even when we attempt to fixate, the visual gaze is never motionless, as we continuously perform miniature oculomotor movements termed as fixational eye movements. The fastest...
Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit
Numerous studies have shown that neuronal representations in sensory pathways are far from static but are instead strongly shaped by the complex properties of the sensory inputs they receive. Adaptati...
Serotonergic Input into the Cerebellar Cortex Modulates Anxiety-Like Behavior
Because of the important roles of both serotonin (5-HT) and the cerebellum in regulating anxiety, we asked whether 5-HT signaling within the cerebellum is involved in anxiety behavior. Physiological 5...
Long-Term Excessive Alcohol Consumption Enhances Myelination in the Mouse Nucleus Accumbens
Chronic excessive alcohol (ethanol) consumption induces neuroadaptations in the brain's reward system, including biochemical and structural abnormalities in white matter that are implicated in addicti...
Salience-Dependent Disruption of Sustained Auditory Attention Can Be Inferred from Evoked Pupil Responses and Neural Tracking of Task-Irrelevant Sounds
Stimulus-driven attention allows us to react to relevant stimuli (and imminent danger!) outside our current focus of attention. But irrelevant stimuli can also disrupt attention, for example, during l...
Adaptation with Naturalistic Textures in Macaque V1 and V2
Adaptation affects neuronal responsivity and selectivity throughout the visual hierarchy. However, because most prior studies have tailored stimuli to a single brain area of interest, we have a poor u...
VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence
Opioids initiate dynamic maladaptation in brain reward and affect circuits that occur throughout chronic exposure and withdrawal that persist beyond cessation. Protracted abstinence is characterized b...
Superior Colliculus Controls the Activity of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in an Asymmetrical Manner
Dopaminergic (DA) neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) play a crucial role in controlling animals’ orienting and approach behaviors toward relevant envi...