Journal of Neuroscience
Articles in this Issue
Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease
Engrams and Memory: My Scientific “Eras Tour”
Memories are widely thought to be encoded by sparse populations of neurons, often referred to as engrams. My entry into this field began with a 2001 report in this journal showing that overexpression...
Endothelial <i>Adgrl2</i> Expression and Alternative Splicing Controls the Cerebrovasculature
Central nervous system development requires parallel but interrelated processes of neural circuit assembly and vascularization. Intersecting between these two processes is the cell-adhesion G-protein...
Mild Neonatal Hypoxia Targets Synaptic Maturation, Disrupts Adult Hippocampal Learning and Memory, and Is Associated with CK2-Mediated Loss of Synaptic Calcium-Activated Potassium Channel KCNN2 Activity
Preterm infants frequently sustain brief hypoxic insults of unclear clinical significance. Since preterm survivors commonly sustain lifelong memory impairment without apparent gray matter injury, we t...
Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery after Spinal Cord Injury
Spinal cord injury (SCI) causes progressive secondary damage, yet translation of hypothermia, one of the few preclinical neuroprotectants, has been limited by slow, equipment-dependent cooling that ra...
The Comodification of Brain Activity, Functional Connectivity, and Behavior Following Learning
Skill acquisition is a complex process which involves experience-dependent reorganization of functional brain networks. Learning-derived modifications have been widely reported, in both task-evoked ne...
Bed Nucleus of Stria Terminalis Enkephalin Neurons Contribute to Depletion-Induced Salt Appetite
The overconsumption of sodium contributes to a wide range of detrimental health conditions. Thus, it is imperative to gain a better understanding of the neural mechanisms driving sodium appetite. Here...
Dichotomous Regulation of Social Behaviors by Nucleus Accumbens Neurons in Female and Male Syrian Hamsters
Social relationships, including dominance status, are powerful regulators of mental health, and social experiences impact the continued expression of these behaviors. However, very little is known abo...
Epigenetic Repression of the Serotonergic Neuron Phenotype Following Adolescent Binge Drinking Is Restored through Inhibition of Proinflammatory Signaling by Exercise and Glycyrrhizic Acid
The serotonergic system regulates diverse social and emotional processes, including formation of social networks that continue to mature throughout adolescence. In adolescent intermittent ethanol (AIE...
Endothelial NMDA Receptor Involvement in Retinal Neurovascular Damage Following Prenatal Alcohol Exposure in a Mouse Model
Prenatal alcohol exposure (PAE) induces neurodevelopmental damage leading to fetal alcohol spectrum disorders (FASD) by altering both brain and ocular development. Recent data showed that PAE impairs...
Optogenetic Hedonic Hotspots in the Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness “Liking”
Hedonic hotspots are localized brain sites where appropriate stimulations can amplify the hedonic impact of palatable tastes, measured as increases in affective orofacial “liking” reactions to sweetne...
Spatial Subdomains in the Optic Tectum for the Encoding of Visual Information
Neurons across the visual system provide estimates of the visual features they encode. However, the reliability of those estimates can vary across the neuronal population. Here, we use information the...
Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity
Long-term regulation of inhibitory synaptic strength is crucial for maintaining excitation–inhibition (E/I) balance in cortical circuits. In this study, we identify neuroligin-2 (Nlgn2) as a critical...
Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia
Mesocorticostriatal dopamine projections are crucial for value learning, motivational control, and cognitive functions. However, while dopamine's role in value learning as reward-prediction-error (RPE...