Journal of Neuroscience
Articles in this Issue
Shifts in Context Affect Hippocampal Activity and the Sequence of Recall
A Direct Auditory Subcortical Route to the Amygdala Associated with Fear in Humans
Rapid and efficient fear processing is essential for survival. In vision, this function is supported by a well-characterized subcortical pathway consisting of direct projections from the pulvinar of t...
Sleep-Like Slow Waves during Wakefulness Mediate Attention and Vigilance Difficulties in Adult Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is characterized by behavioral variability and heightened inattention associated with increased mind wandering (MW) and mind blanking (MB). Individuals...
Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus
The human circadian rhythm is controlled by central and peripheral clocks, primarily by the central clock in the suprachiasmatic nucleus (SCN). We investigated the diurnal variation of basic metabolis...
Suppression of In Vitro Epileptiform Activity by GABA Transaminase Inhibition Is Dependent on GABA <sub>B</sub> Receptors and GABA Transporter Type 1 (GAT1)
Many antiepileptic drugs act by modulation of ionotropic GABA A receptors or effects on extracellular GABA concentrations. Metabotropic GABA...
Motoneurons Inhibitory Synapses Homeostatically Respond to Neuronal Activity and Modulate Amyotrophic Lateral Sclerosis Pathogenesis
Alterations in excitation/inhibition (E/I) balance and changes in motor neurons (MN) activity may contribute to MN vulnerability in ALS. The balance of pathogenic versus adaptive changes occurring in...
Single-Cell-Resolution Fate Mapping Reveals Embryonic Venous Origins of Fenestrated Hindbrain Choroid Plexus Vasculature
In the brain, endothelial cell (EC) subtypes characterized by blood–brain barrier (BBB) properties or fenestrated pores form essential brain–blood interfaces and exhibit markedly distinct permeability...
GABA and Glx Distinctively Predict Motor Learning and Retention in Young and Older Adults
Gamma-aminobutyric acid (GABA) and glutamate are fundamental in neural plasticity. Motor learning is predicted by baseline levels of these metabolites and their modulation in the sensorimotor cortex (...
A Spinal Origin for the Obligate Flexor Synergy in the Nonhuman Primate: Implications for Control of Reaching
Stroke survivors frequently develop the flexor synergy, an obligate cocontraction of shoulder abductors and elbow flexors. The neural substrate has to date proven elusive. Here we trained two healthy...
Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice
General anesthesia (GA) induces reversible unconsciousness for surgery, yet mechanisms underlying bidirectional transitions of states of consciousness during GA remain largely unknown. Here, we focuse...
Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems
Although music has been associated with increased prosocial behavior, the underlying mechanisms for music-facilitated social benefits are not known. We test the hypothesis that chord progressions prom...
Neurochemical Correlates of Mind-Wandering and Meta-Awareness
Mind-wandering frequently occurs throughout daily life, diverting attention away from both goal-oriented behavior and internal mental operations. The experience of mind-wandering varies in both the de...
Alpha Oscillations Track the Projection of Reactivated Memories into Conscious Awareness
By definition, episodic memory is a conscious phenomenon. Memory traces reactivated by the hippocampus and reinstated in the sensory cortices need to enter conscious awareness for them to be re-experi...