Journal of Neuroscience
Articles in this Issue
Cholinergic Dynamics in the Septo-hippocampal System Provide Phasic Multiplexed Signals for Spatial Novelty and Correlate with Behavioral States
In the hippocampal formation, cholinergic modulation from the medial septum/diagonal band of Broca is known to correlate with the speed of an animal's movements at subsecond timescales and also suppor...
Network Dysfunction Precedes Neurodegeneration in a dox-Regulatable TDP-43 Mouse Model of ALS-FTD
Neuronal hyperexcitability is a hallmark of amyotrophic lateral sclerosis (ALS), but its relationship with the TDP-43 aggregates that comprise the predominant pathology in over 90% of ALS cases remain...
Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles
While the hyper- and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, the lack of an overarching neurobio...
The Development of Neural Inhibition across Species: Insights from the Hurst Exponent
The maturation of inhibitory neurons is crucial for regulating plasticity in developing brains. Previous work has suggested that the Hurst exponent, the measure of autocorrelation in time series, refl...
Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition
Early structural and molecular development of the human cortex is extensively studied, but little is known about the development of neuronal activity across cortical regions. We used dense array elect...
Beyond Divisive Normalization: Scalable Feedforward Networks for Multisensory Integration Across Reference Frames
The integration of multiple sensory inputs is essential for human perception and action in uncertain environments. This process includes reference frame transformations as different sensory signals ar...
A Common Representational Code for Event and Object Concepts in the Brain
Events and objects are two fundamental ways in which humans conceptualize their experience of the world. Despite the significance of this distinction for human cognition, it remains unclear whether th...
The Time Course of Phonological Encoding: Insights from Time-Resolved MVPA
To produce a word, speakers need to decide which concept to express, select an appropriate item from the mental lexicon, and spell out its phonological form. The temporal dynamics of these processes r...
BoNT Injection into Temporomandibular Joint Alleviates TMJ Pain in Forced Mouth Opening Mouse Model
Temporomandibular disorder (TMD) significantly impairs the quality of life of patients due to chronic pain and limited jaw function. Many treatment options have been used such as pharmacologic managem...
Epigenetic Repression of miR-216a-3p via H3K27me3 Drives STIM1-Mediated Neuronal Excitability in Neuropathic Pain
Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance
In temporal lobe epilepsy, interictal spikes (IS)—hyper-synchronous bursts of network activity—occur at high rates in between seizures. We sought to understand the influence of IS on working memory by...