Journal of Neuroscience
Articles in this Issue
PolyQ-Expansion of Ataxin-2 Disrupts Microtubule Stability and Impairs Axon Outgrowth
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by mislocalization and aggregation of proteins in motor neurons. Ataxin-2 (ATXN2), an RNA-binding protein harbori...
Acute Restraint Stress and Pain Modulation Depend on the Interaction between the Periaqueductal Gray and the Lateral Septum
Acute restraint stress (RS) causes analgesia in humans and laboratory animals, but the underlying mechanisms are unknown. Recently, we have shown that a multinodal circuitry between the dorsal lateral...
Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task
Behavioral outcomes are rarely certain, requiring subjects to discriminate between available choices by using feedback to guide future decisions. Probabilistic reversal learning (PRL) tasks test subje...
Attention Defines the Context for Implicit Sensorimotor Adaptation
The sensorimotor system continuously uses error signals to remain precisely calibrated. We examined how attention influences this automatic and implicit learning process in humans (male and female). F...
The Somatostatin Pathway Projected from the Basal Forebrain to the Lateral Habenula Promotes Isoflurane Anesthesia Recovery
The basal forebrain (BF) acts as a pivotal relay station in the transmission of arousal signals, projecting to both cortical and subcortical structures. Among its downstream targets is the lateral hab...
Mechanisms of Long-Term Nonexternally Reinforced Preference Change: Functional Connectivity Changes in a Longitudinal Functional MRI Study
Behavioral change studies mostly focus on external reinforcements to modify preferences. Cue-approach training (CAT) is a paradigm that influences preferences by the mere association of stimuli, senso...
mWAKE in the Central Amygdala Regulates Fear Learning and Memory
The central amygdala (CeA) is an important neuronal hub that integrates external sensory inputs and information about internal states to regulate a range of innate and learned behaviors, including fea...
Stopping Muscle Contractions and Relaxations during Action Inhibition Involves Global and Targeted Control Dependent on Muscle State
The mechanisms underpinning the stopping of muscle contractions and relaxations during action inhibition remain unclear. Central stop commands may be targeted and act on task-active muscles only, or i...
Disrupted Calcium Dynamics in Reactive Astrocytes Occur with End Feet–Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer's Disease
While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer's disease (AD) and related dementias, the dynamic relationship between reactive astrocy...
The Extralemniscal System Modulates Early Somatosensory Cortical Processing
Sudden and surprising sensory changes signal environmental events that may require immediate behavioral reactions. In mammals, these changes engage nonspecific “extralemniscal” thalamocortical pathway...
Annual Renewal: Why the Society for Neuroscience Meeting Keeps Drawing Me Back
Registering for my 35th consecutive Society for Neuroscience Annual Meeting in early July 2025, I realized the Conference is the longest standing yearly ritual of my life. I couldn't help wondering, w...