Journal of Neuroscience
Articles in this Issue
Experience the Music of the Mind with <i>Art of Neuroscience</i> 15th Edition
The disciplines of art and science have always deeply influenced each other and continue to do so. With Art of Neuroscience, we attempt to capture this relationship by highlighting the art inspired by...
Spatial Frequency Tuning Follows Scale Invariance in the Human Visual Cortex
Our visual system can recognize patterns across many spatial scales. A fundamental assumption in visual neuroscience is that this ability relies on the putative scale-invariant properties of receptive...
The Interplay of Bottom-Up Arousal and Attentional Capture during Auditory Scene Analysis: Evidence from Ocular Dynamics
The auditory system plays a crucial role as the brain's early warning system. Previous work has shown that the brain automatically monitors unfolding auditory scenes and rapidly detects new events. He...
Baker–Gordon Syndrome-Associated Synaptotagmin-1 Mutations Reduce Synaptic Strength in Mouse Primary and Human-Induced Neuronal Culture Models
Baker–Gordon syndrome (BAGOS) is a neurodevelopmental disorder (NDD) linked to a series of de novo mutations in the synaptic vesicle protein, Synaptotagmin-1 (SYT1). SYT1 is the major calcium sensor f...
The Spatio-Temporal Dynamics of Phoneme Encoding in Aging and Aphasia
During successful language comprehension, speech sounds (phonemes) are encoded within a series of neural patterns that evolve over time. Here we tested whether these neural dynamics of speech encoding...
Natural Scene and Object Perception Based on Statistical Image Features: Psychophysics and EEG
Recent studies have suggested the importance of statistical image features in both natural scene and object recognition, while the spatial layout or shape information is still important. In the presen...
The Increased Activity of CaV3.2 Channels Contributes to Nociceptors’ Hyperexcitability and Chronic Neuropathic Pain Following Spinal Cord Injury in Mice
Following spinal cord injury (SCI), up to 60–70% of patients develop chronic neuropathic pain. SCI-induced neuropathic pain (SCI-NP) is often lifelong and therapeutically intractable, leading to a sev...
Prolonged Light Exposure Induces Long-Lasting Retinal Wave Plasticity via Retrograde Melanopsin-Dopamine Signaling
The spontaneous activity in the developing retina is necessary for the maturation of the neuronal circuitry in visual-associated brain areas. While previous studies have shown that the activation of i...
Chimeric Music Reveals an Interaction of Pitch and Time in Electrophysiological Signatures of Music Encoding
Pitch and time are the essential dimensions defining musical melody. Recent electrophysiological studies have explored the neural encoding of musical pitch and time by leveraging probabilistic models...
Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity
At autopsy, >95% of ALS cases display a redistribution of the essential RNA binding protein TDP-43 from the nucleus into cytoplasmic aggregates. The mislocalization and aggregation of TDP-43 is bel...
Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons
In taste buds, the GPCR heterodimer TAS1R2 + TAS1R3 is considered the canonical taste receptor for sugars and noncaloric sweeteners. Nevertheless, evidence has accumulated for the presence of an alter...
Functional Near-Infrared Spectroscopy Reveals Functional Rewiring between Macaque Motor Areas Following Postinfarction Recovery of Manual Dexterity
Poststroke motor recovery relies on the functional reorganization of motor-related cortical areas to compensate for damaged neural circuitry related to motor functions. Functional near-infrared spectr...
Contributions of Distinct Attention Mechanisms to Saccadic Choices in a Gamified, Dynamic Environment
Visuospatial attention is key for parsing visual information and selecting targets to look at. Based on regimented laboratory tasks, it is now well-established that three types of mechanism determine...
The Human Insula Reimagined: Single Neurons Respond to Simple Sounds during Passive Listening
The insula is critical for integrating sensory information from the body with that arising from the environment. Although previous studies suggested that posterior insula is sensitive to sounds, these...
Midbrain Dopamine Warps Subjective Time via Threshold Setting But Not Clock Speed
Interval timing is an evolutionarily well-preserved function that presents similar behavioral signatures across different species. However, the neural basis of interval timing remains an open question...