Journal of Neuroscience
Articles in this Issue
Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease
The nature of motor deficits in Parkinson disease (PD) and aspects of their improvements with ʟ-DOPA replacement therapy (LDRT) offer potential insights into striatal dopamine actions. The defining an...
The Amygdala Regulates Social Motivation for Selective Vocal Imitation in Zebra Finches
Imitation plays a key role in the acquisition of speech and cultural behaviors. Studies suggest that social interaction facilitates imitative learning, indicating that neural circuits involved in soci...
Neural Signatures of Flexible Multiple Timing
The human ability to track overlapping and asynchronous time intervals is crucial for a myriad of tasks, from engaging in conversation to driving a car. Additionally, unexpected events can trigger rap...
PVN–NAc Shell–VP Circuit OT and OTR Neurons Regulate Pair Bonding via D2R and D1R
Previous studies have found that several neurochemicals are involved in formation of pair bonding. However, the circuit mechanisms underlying pair bonding, especially how these chemicals interact in t...
Atypical Cadherin FAT2 Is Required for Synaptic Integrity and Motor Behaviors
In humans, mutations or deletions of atypical FAT cadherin genes are linked to autism spectrum disorder and cerebellar ataxia. However, their large genomic size and the enormous size of their encoded...
Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell
The nucleus accumbens (NAc) is critical to goal-directed behaviors as the main input structure for limbic pathways to the basal ganglia. The NAc shell is composed of inhibitory projection neurons that...
Sex Differences in Histamine Regulation of Striatal Dopamine
Dopamine modulation of the basal ganglia differs in males and females and is implicated in numerous neuropsychiatric conditions, including some, like Tourette syndrome (TS) and attention deficit hyper...
Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex
Chlorpyrifos is an organophosphorus pesticide used extensively in agricultural and residential settings for nearly 60 years. Gestational, subacute exposure to chlorpyrifos is linked to increased preva...
Target Selection Signals Causally Influence Human Perceptual Decision-Making
The ability to form decisions is a foundational cognitive function which is impaired across many psychiatric and neurological conditions. Understanding the neural processes underpinning clinical defic...
Zooming In and Out: Selective Attention Modulates Color Signals in Early Visual Cortex for Narrow and Broad Ranges of Task-Relevant Features
Research on feature-based attention has shown that selecting a specific visual feature (e.g., the color red) results in enhanced processing in early visual cortex, providing the neural basis for the e...
The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice
Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the...
CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity
The chemokine CXCL12 is a highly conserved peptide that regulates homeostatic processes in the brain throughout life. Recent work shows that CXCL12 increases dendritic spine density in cortical neuron...
Continuous Diffusion-Detected Neuroplasticity during Motor Learning
How does our brain transform when we encounter a new task? To fully answer this question, comparing brain states before and after learning may not be enough, but rather an ongoing, continuous monitori...
Functional and Regional Specificity of Noradrenergic Signaling for Encoding and Retrieval of Associative Recognition Memory in the Rat
Recognition of a familiar object in a novel location requires retrieval of the former object–place association and encoding of novel information. Such object-in-place (OiP) memory recruits a neural ne...
Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening
Over the course of development, functional sensory representations emerge in the visual cortex. Prior to eye opening, modular patterns of spontaneous activity form long-range networks that may serve a...