Journal of Neuroscience
Articles in this Issue
A New Optogenetic Tool to Investigate the Role of Dopamine Signaling in the Basal Ganglia
Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-Challenged <i> Disc1 <sup>+/−</sup> </i> Mice
Neuronal activity in the olfactory bulb (OB) drives coordinated activity in the hippocampal–prefrontal network during early development. Inhibiting OB output in neonatal mice disrupts functional devel...
Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation
The suprachiasmatic nucleus (SCN) serves as the central circadian clock in mammals, coordinating daily rhythms in both behavior and physiology. In the SCN, gastrin-releasing peptide (GRP)-producing ne...
Attention Alters Population Spatial Frequency Tuning
Spatial frequency (SF) selectivity serves as a fundamental building block within the visual system, determining what we can and cannot see. Attention is theorized to augment the visibility of items in...
Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages
This study examined how amyloid burden affects structural and functional brain network topology in subjective cognitive decline (SCD), a risk condition for Alzheimer's disease (AD). Functional and str...
Threonine-53 Phosphorylation of Dopamine Transporter Dictates κ-Opioid Receptor-Mediated Locomotor Suppression, Aversion, and Cocaine Reward
Dynorphin (DYN)/κ-opioid receptor (KOR) activation contributes to aversion, dysphoria, sedation, depression, and enhanced psychostimulant-rewarding effects by inhibiting dopamine (DA) release. The pre...
Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents
Hippocampal sharp-wave ripples (SWRs) are intermittent, fast synchronous oscillations that play a pivotal role in memory formation. It has been well established that SWRs occur during “consummatory be...
Regional Excitatory–Inhibitory Balance Relates to Self-Reference Effect on Recollection via the Precuneus/Posterior Cingulate Cortex–Medial Prefrontal Cortex Connectivity
Self-related representation can enhance perception and memory—a phenomenon known as the self-referential effect (SRE). While SRE has been linked to the activation of the default mode network (DMN), in...
Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain
Reverse transcriptase (RT) activity in the human brain has been inferred through somatic retroinsertion/retrotransposition events; however, actual endogenous enzymatic activities and sources remain un...
The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response
Chronic pain presents a widespread and complex clinical puzzle, necessitating theoretical approaches. This study expands upon our evolving comprehension of the brain’s top-down information processing,...
Complex Impact of Stimulus Envelope on Motor Synchronization to Sound
The human brain tracks temporal regularities in acoustic signals faithfully. Recent neuroimaging studies have shown complex modulations of synchronized neural activities to the shape of stimulus envel...
The Molecular Substrates of Second-Order Conditioned Fear in the Basolateral Amygdala Complex
Rats quickly learn to fear a stimulus (e.g., a light) that signals brief but painful footshock. The consolidation of this first-order conditioned fear requires transcription and translation of specifi...
Heterogeneous Effects of Cognitive Arousal on the Contrast Response in Human Visual Cortex
While animal studies have found that arousal states modulate visual responses, direct evidence for effects of arousal on human vision remains limited. Here, we used fMRI to examine effects of cognitiv...