Journal of Neuroscience
Articles in this Issue
Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms
Sensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are critical for transmitting somatosensory information, including pain, to the central nervous system. In these neurons, a...
Evidence for Abstract Codes in Parietal Cortex Guiding Prospective Working Memory
The recent past helps us predict and prepare for the near future. Such preparation relies on working memory (WM) which actively maintains and manipulates information providing a temporal bridge. Numer...
Reduced Pavlovian Value Updating Alters Decision-Making in Sign-Trackers
Successful reward-guided behavior relies not only on learning actions to obtain rewards but also on learning cues that predict the reward, which motivate and prepare the animal to pursue and consume i...
Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy
KCNQ2 potassium channel variants are linked to developmental and epileptic encephalopathy (DEE). However, the mechanisms by which pathogenic variants, especially those outside known hotspots, such as...
Specific Glutamatergic Projection to Claustrum for Regulating Methamphetamine Abstinence Anxiety-Like Behaviors
Methamphetamine (METH) abstinence anxiety is a common METH abstinence symptom, which drives METH relapse. Our previous study found that claustrum (CL) is involved in coding abstinence anxiety-like beh...
Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input
Short-term plasticity occurs at synapses throughout the cerebellum, raising the question of how such plasticity affects cerebellar processing in vivo. To address this issue, we recorded responses of m...
Domain-General Neural Effects of Associative Learning and Expectations on Pain and Hedonic Taste Perception
Predictive cues significantly influence perception through associative learning. However, it is unknown whether circuits are conserved across domains. We investigated how associative learning influenc...
Survey of Hippocampal Responses to Sound in Naive Mice Reveals Widespread Activation by Broadband Noise Onsets
Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naive subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels...
Altered Regional Brain Activity Underlying the Higher Postoperative Analgesic Requirements in Abstinent Smokers: A Prospective Cohort Study
Perioperative abstinent smokers experience heightened pain sensitivity and increased postoperative analgesic requirements, likely due to nicotine withdrawal-induced hyperalgesia. However, the underlyi...
Respiration Shapes the Neural Dynamics of Successful Remembering in Humans
Respiration has been shown to impact memory retrieval, yet the neural dynamics underlying this effect remain unclear. Here, we investigated how respiration shapes both behavioral and neural expression...
HDAC6 Inhibition Reduces Seeded Tau and α-Synuclein Pathologies in Primary Neuron Cultures and Wild-Type Mice
A previous compound screen identified two molecules with histone deacetylase 6 (HDAC6) inhibitory activity that reduced Alzheimer's disease (AD)-like tau inclusions in a primary rat cortical neuron mo...
The Contribution of the Locus Ceruleus–Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State
Understanding how pupil-linked arousal couples with cortical state is crucial for uncovering the neural mechanisms underlying brain state-dependent cognitive and sensory processing. Pupil size fluctua...
Orthogonal-Rotational Dynamics Supports Efficient Encoding and Updating for Streaming Information in Working Memory
We rely on the working memory (WM) to organize, store, and process the perpetual stream of information. Efficient encoding and processing of WM requires a framework that (1) separates individual memor...
Sharpened Visual Memory Representations Are Reflected in Inferotemporal Cortex
Humans and other primates can robustly report whether they have seen specific images before, even when those images are extremely similar to ones they have previously seen. Multiple lines of evidence...
High-Pass Filtering through Short-Term Synaptic Facilitation Amplifies Low-Frequency Modulation of Bursting Input
Regular rhythmic activity typically produces stereotypical synaptic responses, masking dynamics due to short-term synaptic plasticity (STP). Multiple-frequency (e.g., Poisson-like) inputs unveil canon...
Contributions of Sound Localization Cues to Azimuth Tuning in the Auditory Midbrain
Neurons in the central nucleus of the inferior colliculus exhibit spatial receptive fields due to underlying neural sensitivity to acoustic cues that covary with sound source location, including inter...
Diversity in Whisking-Related Dynamics of Layer 5 Neurons in the Motor Cortex
Rodents manipulate their vibrissae to actively interact with their environment. The vibrissa area of the primary motor cortex (vM1) is a central player in orchestrating the rhythmic whisker movement,...
Task-Dependent Visual Topographic Connectivity in the Human Cerebellum
The role of the cerebellum has long been thought to be limited to sensorimotor processes. Recently, its involvement in a broader set of cognitive and associative tasks has challenged this view. Recent...
Visual Motion Processing in The Tree Shrew Superior Colliculus
Recent research has established that the superior colliculus (SC) plays a key role in visual motion processing and visually guided behaviors. However, differences across species have made it difficult...
Gene Expression-Based Lesion–Symptom Mapping: <i>FOXP2</i> and Language Impairments after Stroke
Chronic language impairments, aphasia, are a common consequence of stroke, yet the factors influencing their severity remain poorly understood. Although lesion location is widely recognized as a key d...
Early and Late Phases of Sensory-Evoked Olfactory Bulb Inhibition Are Mediated by Parallel Local Circuits: Attenuation of Fast Tufted Cell Axo-dendritic Inputs to Granule Cells by Adenosine A1 Receptors
Across species, simple olfactory operations primarily utilize long-range excitatory interconnections. More complex tasks, such as fine odor discrimination and plasticity, rely on local inhibitory circ...