Journal of Neuroscience
Articles in this Issue
Erratum: Jing and Wu et al., “Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance”
Erratum: “Behavioral and Neural Mechanisms of Face-Specific Attention during Goal-Directed Visual Search”
Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus
Neural activity is a fundamental driver of early circuit assembly, yet how it shapes the distribution of inhibitory neurons across sensory networks remains poorly understood. Establishing an appropria...
COMMD1 Induces Copper Deficiency of SOD1 by Inhibiting the Palmitoylation of CCS in ALS
Mutations in superoxide dismutase 1 (SOD1) compromise its metal-binding capacity, resulting in protein misfolding and aggregation, which ultimately induces cellular apoptosis in amyotrophic lateral sc...
When Anticipation Is Not Enough: A Mixture of Robust and Adaptive Feedback Control Strategies Improves Reaching in Dynamic Environments
Successful goal-directed movements depend on the central nervous system's (CNS) ability to handle diverse physical interactions. The CNS is thought to handle different dynamical contexts through three...
TNF-α Deficiency Reduces Parvalbumin Neuron Density, Impairs Homeostatic Plasticity, Disrupts Synaptic Excitation–Inhibition Balance, and Prevents Critical Period Closure in the Auditory Cortex
Tumor necrosis factor-alpha (TNF-α), a pleiotropic cytokine, modulates neuronal functions under both physiological and pathological conditions. In the auditory system, it is required for refinement of...
Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses
One of the first steps in processing visual information is to split the light signal captured by photoreceptors into complementary ON and OFF pathways, which separately encode increases and decreases...
Dynamic and Context-Dependent Modulation of Somatosensory Input in the Primate Primary Motor Cortex
During voluntary movement, somatosensory input is attenuated, a phenomenon known as sensory gating, which may prevent the CNS from being overwhelmed by predictable afferent feedback not essential for...
Analysis of Corneal Axons Remodeling In Vivo during Development and Aging Using Long-Term Imaging in Mice
The cornea serves as a critical interface between the external environment and the inner eye tissues, such as the retina. Its rich sensory innervation is essential to mediate protective reflexes and s...
A Novel Cooperative Behavior Assay in Rats Reveals Distinct Social Coordination Strategies of Increasing Complexity and Social Reciprocity Deficits in a Model of Fragile X Syndrome
Cooperative behavior, the ability of individuals to coordinate their actions toward shared goals, is fundamental to survival and social success across species. However, the mechanisms supporting coope...
Distinct Response Selectivity Changes in the Primary Visual and Parietal Cortex during Visual Discrimination Learning
When animals learn the behavioral relevance of sensory features, response selectivity in primary sensory areas increases for those features. However, the effect of learning on neuronal activity in hig...
Regulation of Schwann Cell–Axon Interactions in Nerve Development: The Role of Slit2 in Axonal Sorting
Radial sorting of axons is a critical process in nerve development, ensuring proper segregation of axons to form myelinated and unmyelinated Schwann cell–axon units. This process is regulated by signa...
Brain Representations of Natural Sound Statistics
Natural sound textures (e.g., rain, crackling fire) are perceptually defined by time-averaged summary statistics. While previous studies have examined neural responses to natural sounds, little is kno...
Targeting the HMGB1–TLR4 Axis Alleviates Neuropathic Pain-Associated Cognitive Deficits
Cognitive deficits associated with chronic pain pose a significant burden on a patient's quality of life. Emerging evidence indicates that Toll-like receptor 4 (TLR4), a pattern recognition receptor i...