Journal of Neuroscience
Articles in this Issue
Frontocentral Neural Dynamics Reflect Decisions about When to Act
The Hidden Benefits of Noise: Low-Frequency tRNS and Dynamic Visual Noise Enhance Visual Processing
Sensory and perceptual processing are inherently shaped by both internal and external noise sources. While noise is typically seen as disruptive, it can, under certain conditions, enhance the detectio...
Diverse Transcriptional Alterations in V2a Propriospinal Neurons Following Spinal Cord Injury
Propriospinal neurons play crucial roles in recovery of function after spinal cord injury. The V2a class in particular contributes significantly to recovery of locomotor and respiratory function after...
Semantic Representational Strength in the Precuneus and Lateral ATL Predicts Successful Factual Learning
Learning novel facts is central to modern life. While cortical regions involved in this process have been identified, the neural substrates underlying successful knowledge acquisition have remained el...
Dysfunction of Unc119, a Transducin-Binding Protein, Leads to Cone–Rod Dystrophy through Activating JAK-Stat and NF-κB Inflammatory Pathways in the Mouse Retina
Transducin is a heterotrimeric G-protein that is a component of the phototransduction cascade in rod and cone photoreceptor cells of the retina. Gnat1, a rod-specific transducin α-subunit, regulates l...
CaMKII Drives Synaptic Maturation by Coordinating Spine Remodeling and Receptor Segregation via Liquid–Liquid Phase Separation
A hallmark of mature excitatory synapses is their localization on dendritic spines, which increase in number and enlarge during development. Recent super-resolution studies have uncovered another key...
Trigeminal Motor Nucleus Regulates Microstructure of Feeding Behavior without Affecting Total Food Intake
Feeding is critical for animal survival and is tightly regulated by designated neural circuits. Several brain regions have been implicated in feeding regulation, including the hypothalamus, amygdala,...
Spontaneous Alpha-Band Lateralization Extends Persistence of Visual Information in Iconic Memory by Modulating Cortical Excitability
Pre-stimulus alpha oscillations in the visual cortex modulate neuronal excitability, influencing sensory processing and decision-making. While this relationship has been demonstrated mostly in detecti...
Intrinsic Neural Timescales Relate to Event-Related Activity—Key Role for Intracolumnar Connections
The relationship of the brain’s intrinsic neural timescales (INTs) during the resting state with event-related activity in response to external stimuli remains poorly understood. Here, we bridge this...
Intrinsic Dendritic Integration Features of Prefrontal Layer 5 Pyramidal Cell Subclasses
The prefrontal cortex (PFC) is an associative center that integrates various inputs to support cognition. Layer 5 pyramidal cells are themselves associative centers, as their dendrites span all cortic...
Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty
Converging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose b...
Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity
Synapse formation requires the accumulation of cytomatrix proteins and voltage-gated Ca 2+ channels (VGCCs) at presynaptic active zones (AZs). At...
Selective Attention Shapes Neural Representations of Complex Auditory Scenes: The Roles of Object Identity and Scene Composition
Everyday auditory scenes contain overlapping sound objects, requiring attention to isolate relevant objects from irrelevant background objects. This study examined how selective attention shapes neura...
Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes
The granular retrosplenial cortex (RSG) supports memory, orientation, and fear processing. The mouse RSG contains several cell types that are remarkably distinct from those found in other cortical reg...
Neural Responses Underlying Interaural Time Difference Discrimination as a Function of Sensory Reliability in the Barn Owl
Discrimination of sensory stimuli is fundamentally constrained by the information encoded in neuronal responses. In the barn owl, interaural time difference (ITD) serves as a primary cue for azimuthal...