Journal of Neuroscience
Articles in this Issue
Erratum: Chen et al., “Dopamine and Norepinephrine Differentially Mediate the Exploration–Exploitation Tradeoff”
Erratum: Alexander et al., “Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory”
Stress Management in Athletes: Predictive Effects of Sleep Deprivation-Induced Cognitive Control Changes on Competition Performance
Effective stress management is crucial for optimal competition performance in athletes. Sleep deprivation (SD) can elevate physiological and psychological stress, and the SD-changed cognitive and emot...
Cross-Sensitization between Binge Eating and Binge Drinking in a Novel C57BL/6NJ Murine Model of Disease Comorbidity Requires PDE4B Activation
There is a high rate of comorbidity between binge eating (BE) and binge drinking (BD) behaviors, suggesting a common neuropathology. Recently, phosphodiesterase 4B...
Preferential Localization of STIM1 to Dendritic Subsurface ER Structures in Mouse Purkinje Cells
The endoplasmic reticulum (ER) is the largest intracellular Ca 2+ store, serving as the source and sink of intracellular Ca 2+ . The ER Ca 2+ store is continuous yet organized into distinct subcompart...
Medial Orbitofrontal, Prefrontal, and Amygdalar Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making
The medial orbitofrontal cortex (mOFC) has been implicated in shaping decisions involving reward uncertainty, in part by using memories to infer future outcomes. This region is interconnected with oth...
Hippocampal Neural Stem Cell Exosomes Promote Brain Resilience against the Impact of Tau Oligomers
A promising therapeutic intervention for preventing the onset and progression of Alzheimer's disease is to protect and improve synaptic resilience, a well-established early vulnerability associated wi...
A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat
Temporal dynamics play a central role in models of emotion: “fear” is widely conceptualized as a phasic response to certain-and-imminent danger, whereas “anxiety” is a sustained response to uncertain-...
A2A-Positive Neurons in the Nucleus Accumbens Core Regulate Effort Exertion
Previous work has implicated the nucleus accumbens (NAc) in the regulation of effort, defined as the amount of work an animal is willing to perform for a given reward, but little is known about the sp...
Synchronous Theta Networks Characterize Successful Memory Retrieval
Memory retrieval activates regions across the brain, including not only the hippocampus and medial temporal lobe (MTL), but also frontal, parietal, and lateral temporal cortical regions. What remains...
Ca <sup>2+</sup> -Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory Neurons
In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...
Behavioral Modulation and Molecular Definition of Wide-Field Vertical Cells in the Mouse Superior Colliculus
Visual information can have different meanings across species, and the same visual stimulus can drive appetitive or aversive behavior. The superior colliculus (SC), a visual center located in the midb...
Time-Resolved Aperiodic and Oscillatory Dynamics during Human Visual Memory Encoding
Biological neural networks translate sensory information into neural code that is held in memory over long timescales. Theories for how this occurs often posit a functional role of neural oscillations...
Muscarinic Receptor Activation Preferentially Inhibits Rebound in Vulnerable Dopaminergic Neurons
Dopaminergic subpopulations of the substantia nigra pars compacta (SNc) differentially degenerate in Parkinson's disease and are characterized by unique electrophysiological properties. The vulnerable...
Spatial Processing Enhancement in the Prefrontal Cortex for Rapid Detection of Valuable Objects
It is recently shown that objects with long-term reward associations can be efficiently located during visual search. The neural mechanism for valuable object pop-out is unknown. In this work, we reco...
Neurofibromin Deficiency Alters the Patterning and Prioritization of Motor Behaviors in a State-Dependent Manner
Genetic disorders such as neurofibromatosis type 1 (Nf1) increase vulnerability to cognitive and behavioral disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder. Nf...
The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors
The ability to wait before responding is crucial for many cognitive functions, including reaction time (RT) tasks, where one must resist premature actions before the stimulus and respond quickly once...