Journal of Neuroscience
Articles in this Issue
Evidence of Two Distinct Alpha Rhythms Underlying Attention
KChIP4a is a Biophysical Amplifier of Inhibition in Atypical Dopamine Neurons and Controls Learning from Negative Prediction Errors
Dopamine neurons projecting to distinct brain regions have unique biophysical properties, which are thought to reflect functional specialization. One of these defining properties is the duration of hy...
Effect of Risks, Consequences, and Gravitational Priors on Sensorimotor Coordination: Insights from Weightlessness
When manipulating objects, our brain continuously adjusts grip force (GF) to the variations in load force (LF) generated by our own movements. GF–LF coordination provides a window into the predictive...
Functional Contributions of Quantal and Nonquantal Hair Cell Synaptic Transmission in the Vestibular Periphery
Information about head motion and gravity is conveyed to the brain by vestibular nerve afferents which are subdivided by their spontaneous firing properties into regular and irregular subtypes, though...
Stable Mechanoreceptive Somatotopy in Chronic Low Back Pain: Is Cortical Map Reorganization a Myth?
Chronic low back pain (CLBP) has been linked to maladaptive cortical plasticity in sensorimotor regions, which may contribute to pain persistence through less distinct (“smudged”) somatotopic maps of...
Aberrant Cerebellar-Recipient Thalamic Activity in Two Mouse Models with Prominent Tremor or Bradykinesia
The motor thalamus functions as a gateway between subcortical and cortical motor circuits, relaying information critical to movement initiation and execution. Inputs to motor thalamus from the basal g...
Spatiotemporal Representations of Contextual Associations for Real-World Objects
In the real world, objects always appear in context. Many objects are reliably associated with a certain scene context (e.g., pots appear in kitchens) and other objects that appear in the same context...
Novelty Discrimination of Configural Objects in the Perirhinal and Anterolateral Entorhinal Cortices Is Impacted by Aging
The representational–hierarchical account of object processing characterizes the perirhinal cortex (PRC) as supporting conjunctive representations of object features, such that damage or age-related d...
Manifold Interactions between the Action-Mode Network and Sensorimotor Cortex during Human Motor Learning
Effective motor learning requires a dynamic interplay between specialized sensorimotor circuits and higher-order control networks. How these systems coordinate their activity across the distinct phase...
Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans
Accumulating evidence indicates that aging is associated with degeneration of neural components in the cochlea even before elevated hearing thresholds indicate hearing loss. Yet, it remains uncertain...
Goal-Directed Action Planning Modulates Surround Suppression in the Visual System
Action planning has been traditionally viewed through the lens of motor command specification. However, converging evidence indicates planning also modulates early cortical sensory systems. While prev...
Frequency-Dependent Inhibition during Deep Brain Stimulation of Thalamic Ventral Intermediate Nuclei
Deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (Vim) has been a standard therapy for essential tremor. It has been shown that high-frequency (≥100 Hz) DBS suppresses Vim fir...
Spatiotemporally Distinct Dopamine Domains in the Hippocampus
The neuromodulator dopamine plays a critical role in orchestrating behavior by signaling actions and rewards. Dopamine signaling in the hippocampus is necessary for the formation of long-term memories...