Journal of Neuroscience
Articles in this Issue
Altered Molecular Composition of a Specific Subset of Prefrontal Cortical Excitatory Synapses in Schizophrenia
Abnormal excitatory synaptic transmission in the human prefrontal cortex has been implicated in the pathophysiology of schizophrenia based primarily on genetic evidence. However, changes in synaptic f...
<i>MiR-153</i> Prevents NRF2 Nuclear Translocation to Drive Hypoperfusion-Related Cognitive Deficits by Targeting <i>KPNA5</i>
MiRNA -based therapeutics represent a promising approach for treating multiple diseases, yet the key regulatory miRNAs in chronic cerebral hypoperfusion (CCH)-related cognitive impairment remains uncl...
Characterization of Auditory Responsive Neurons in the Mouse Superior Colliculus to White Noise and Frequency-Restricted Sounds
Locating the source of a specific sound in a complex environment and determining its saliency is critical for survival. The superior colliculus (SC), a sensorimotor midbrain structure, plays an import...
Peripheral Gating of Nociception Investigated with a Decerebrate, Arterially Perfused Preparation of the Rat
There is growing evidence that sensory neurons within the dorsal root ganglia (DRGs) are equipped with mechanisms for “gating” nociceptive information before it enters the central nervous system. Howe...
Spatiotemporal Dynamics of Language Information Representation within the Left Inferior Parietal Lobule Network: An Intracranial SEEG Study
The left inferior parietal lobe (IPL) supports diverse cognitive functions through the finely differentiated yet coordinated interactions of its subregions, including the supramarginal gyrus (SMG), an...
Impact of Elovl5 Deficiency on Cerebellar Excitatory Synaptic Transmission in Mice
The neurotransmitter release and the synaptic vesicle cycle require a specific lipidic composition of presynaptic and vesicle membranes. Phospholipids with long-chain acyl groups are necessary to conf...
Distinct Cortical Populations Drive Multisensory Modulation of Segregated Auditory Sources
Auditory perception can be modulated by other sensory stimuli. However, we do not fully understand the neural mechanisms that support multisensory behavior. Here, while male nonhuman primates detected...
Structural Regeneration and Functional Recovery of the Olfactory System of Adult Zebrafish Following Brain Injury
Olfactory dysfunction is a common outcome of brain injuries, negatively affecting quality of life. The adult mammalian nervous system has limited capacity for olfactory recovery, making it challenging...
Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex
Selectivity for sensory modality characterizes distinct subregions of the human brain, well beyond the primary sensory cortices. We previously identified frontal and posterior cortical regions that ar...
Inhibitory Neurons Marked by the Connectivity Molecule Kirrel3 Regulate Memory Precision
The homophilic adhesion molecule Kirrel3 drives synapse formation between dentate granule (DG) neurons and GABA neurons, and Kirrel3 gene variants are associated with neurodevelopmental disorders in h...