Journal of Neuroscience
Articles in this Issue
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ß-arrestins Form a Protein Complex with Smo and Src Family Kinases to Drive Shh-Mediated Axon Guidance in Spinal Cord Commissural Neurons
A Singular Theory of Sensorimotor Coordination: On Targeted Motions in Space
Gravity has long been purported to serve a unique role in sensorimotor coordination, but the specific mechanisms underlying gravity-based visuomotor realignment remain elusive. In this study, astronau...
Temporally Dissociable Neural Representations of Pitch Height and Chroma
The extraction and analysis of pitch underpin speech and music recognition, sound segregation, and other auditory tasks. Perceptually, pitch can be represented as a helix composed of two factors: heig...
Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region
Huntington's disease (HD), a neurodegenerative disease, affects approximately 30,000 people in the United States, with 200,000 more at risk. Mitochondrial dysfunction caused by mutant huntingtin (mHTT...
Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain
Synaptic vesicle glycoprotein 2A (SV2A) is a presynaptic protein targeted by the antiseizure drug levetiracetam. One or more of the three SV2 genes is expressed in all neurons and is essential to norm...
Microvascular Dysfunction, Mitochondrial Reprogramming, and Inflammasome Activation as Critical Regulators of Ischemic Stroke Severity Induced by Chronic Exposure to Prescription Opioids
The opioid epidemic endangers not only public health but also social and economic welfare. Growing clinical evidence indicates that chronic use of prescription opioids may contribute to an elevated ri...
Development of Differential Sublaminar Feedforward Inhibitory Circuits in CA1 Hippocampus Requires <i>Satb2</i>
Pyramidal cells (PCs) in CA1 hippocampus can be classified by their radial position as deep or superficial and organize into subtype-specific circuits necessary for differential information processing...
Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry
Extracellular matrix (ECM) is a network of macromolecules which has two forms—perineuronal nets (PNNs) and a diffuse ECM (dECM)—both influence brain development, synapse formation, neuroplasticity, CN...
Enhanced Somatosensory Inhibition Sharpens Hand Representation and Sensorimotor Skills in Pianists
Dexterous motor skills, like those needed for playing musical instruments and sports, require the somatosensory system to accurately and rapidly process somatosensory information from multiple body pa...
Single-Nuclei Sequencing Reveals a Robust Corticospinal Response to Nearby Axotomy But Overall Insensitivity to Spinal Injury
The ability of neurons to sense and respond to damage is crucial for maintaining homeostasis and facilitating nervous system repair. For some cell types, notably dorsal root ganglia and retinal gangli...
Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus
While hypothalamic kisspeptin (KP) neurons play well-established roles in the estrogen-dependent regulation of reproduction, little is known about extrahypothalamic KP-producing (KPLS) neurons of the...