Journal of Neuroscience
Articles in this Issue
Peripherally Located Type I Vestibular Hair Cells Are Required for Several Motor Behaviors and Stimulus-Evoked Brainstem Neural Responses in Adult Mice
The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor beh...
Phasic Dopaminergic Signaling Gates REM Sleep Onset through Motivational Mechanisms
Differential and Compensatory Roles for Type I Phosphatidylinositol-4-Phosphate-5-Kinase Isoforms in Retinal Function and Health
Phosphatidylinositol (4,5) bisphosphate [PI(4,5)P 2 ] plays important roles in development, signaling, trafficking, and regulation throughout the nervous system...
Faster But Less Precise: Expectation Enhances Response Speed While Reducing Sensory Fidelity
The brain's remarkable ability to process continuous sensory inputs with adaptive efficiency—balancing flexibility while minimizing metabolic cost—is thought to rely on predictive mechanisms that gene...
Astrocytic FTO-Dependent m6A Demethylation Drives Sevoflurane-Induced Perioperative Neurocognitive Disorders in Mice
The pathogenesis of perioperative neurocognitive disorders (PNDs) involves a complex interplay of genetic vulnerability and environmental insults, with epigenetic regulation acting as a dynamic mediat...
The Intracellular Domain of the Epilepsy Protein PCDH19 Regulates Spine Density in Cortical Neurons In Vivo via <i>Xlr</i> Genes
Mosaic mutations in the X-linked cell adhesion molecule Protocadherin 19 (PCDH19) lead to epilepsy with cognitive impairment, whereas complete absence of functional protein, although possibly linked t...
GPR37 Modulates Remyelination Following Demyelinating Injury
GPR37 has been recognized as a negative regulator of oligodendrocyte myelination. However, its role in demyelination recovery remains unclear. To examine the function of GPR37 in remyelination, we com...
Different Brain Regions Support Deliberation during Food Choice in Disordered and Healthy Eating
The brain is wired to drive behavior toward foods that are high in sugar and fat. Yet, individuals with anorexia nervosa (AN) prefer low-sugar and low-fat foods to the point of starvation and even dea...
Disrupted Maternal Care Alters Neural–Microglia Interactions in the Primate Paralaminar Nucleus (PL) of the Amygdala
Prolonged postnatal maturation of the primate amygdala is thought to be driven, at least partially, by continued neural maturation within the paralaminar nucleus (PL). At birth, the PL is densely popu...
Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility
Cognitive control organizes abstract contexts, stimuli, and actions into hierarchically structured representations. This organization supports flexible behavior but requires updating at multiple level...
Spatiotemporal Divergence between Intrinsic and Evoked Cortical Activity Predicts Visual Detection
The threshold for sensory detection varies with fluctuations in intrinsic cortical activity. When stimulus encoding cortical populations are more excitable, stimuli elicit stronger neural responses th...