Time Persistence of the FMRI Resting-State Functional Brain Networks

Abstract

Time persistence is a fundamental property of many complex physical and biological systems; thus understanding the phenomenon in the brain is of high importance. Time persistence has been explored at the level of stand-alone neural time-series, but since the brain functions as an interconnected network, it is essential to examine time persistence at the network level. Changes in resting-state networks have been previously investigated using both dynamic (i.e., examining connectivity states) and static functional connectivity (i.e., test–retest reliability), but no systematic investigation of the time persistence as a network was conducted, particularly across different timescales (i.e., seconds, minutes, dozens of seconds, days) and different brain subnetworks. Additionally, individual differences in network time persistence have not been explored. Here, we devised a new framework to estimate network time persistence at both the link (i.e., connection) and node levels. In a comprehensive series analysis of three functional MRI resting-state datasets including both sexes, we established that (1) the resting-state functional brain network becomes gradually less similar to itself for the gaps up to 23 min within the run and even less similar for the gap between the days; (2) network time persistence varies across functional networks, while the sensory networks are more persistent than nonsensory networks; (3) participants show stable individual characteristic persistence, which has a genetic component; and (4) individual characteristic persistence could be linked to behavioral performance. Overall, our detailed characterization of network time persistence sheds light on the potential role of time persistence in brain functioning and cognition.