Proceedings of the National Academy of Sciences
Articles in this Issue
Two-dimensional NMR from a single pulse: Reconstructing heteronuclear 2D spectra via off-resonance decoupling and deep neural networks
NMR spectroscopy is ubiquitous in many areas of science, including chemistry, material science, biophysics, and structural biology. Heteronuclear two-dimensional (2D) NMR experiments form the basis of...
CD28-driven ex vivo generation of stem-like memory CD8 <sup>+</sup> T cells bypassing CD3/TCR signaling
Adoptive T cell therapies typically rely on ex vivo CD3/CD28 stimulation, which promotes effector differentiation and limits the persistence of transferred cells. Stem cell–like memory T cells (Tscm),...
Reconfigurable hydrogel interfaces for soft brain electrodes
Forest recovery pathways after fire, drought, and windstorms in southeastern Amazonia
The future of tropical forests depends on their ability to resist and recover from multiple disturbances. Here, we evaluated how edge effects, experimental fires, extreme droughts, and blowdowns resha...
Full solid-state magnetic refrigeration device toward thermal management
The demand for thermal management of electronics is rapidly increasing due to the prosperity of information technology. However, the two major alternatives, convective cooling and vapor compression te...
A discrete serotonergic circuit involved in the generation of tinnitus behavior
Although dysregulated serotonergic neurotransmission has been implicated in the pathophysiology of tinnitus, the precise neural circuit mechanisms underlying this complex sensory neurological disorder...
Connecting habitats, boosting disease resistance: Spatial connectivity enhances amphibian microbiome defenses against fungal pathogen
Disruption of habitat connectivity alters host movement patterns and pathogen exposure in wildlife. Changes in exposure dynamics have led to increased research interest in host-associated microbial co...
The temperature dependence of amyloid <i>β</i> solubility reveals the hydrophobic effect as the main driving force for fibril formation
The aggregation of amyloid proteins into fibrillar and oligomeric aggregates is linked to a number of neurodegenerative diseases. While the disease onset remains elusive in many cases, an understandin...
Cross-linking of collagen fibrils leads to preferential gap zone mineralization in vitro
Collagen mineralization is fundamental to the structure and mechanical properties of bone. Many in vitro models of collagen mineralization have been developed to understand the regulation, from the st...
Fifteen thousand years of bioarchaeological data reveal life history trade-offs among Europe’s first farmers
This paper examines human life history evolution across the transition to agriculture in Europe through an integrated analysis of growth, diet, activity, and demography. Life history theory considers...
Aurora-A drives sorafenib resistance by scaffolding stress granule assembly via phase separation
The mitotic kinase Aurora-A is frequently overexpressed in cancers and contributes to tumor progression and therapy resistance, yet the mechanisms underlying its role in drug resistance remain unclear...
Evolvable AI: Threats of a new major transition in evolution
Evolvable AI (eAI), i.e., AI systems whose components, learning rules, and deployment conditions can themselves undergo Darwinian evolution, may soon emerge from current trends in generative, agentic,...
The crucial and unique role of extreme tropical cyclones in promoting freshwater invasions in China
Climate change induced extreme weather events (EWEs) and invasive species are major threats to global biodiversity and social economy; however, the unique role of EWEs in facilitating biological invas...
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
Most bacteriophages lyse their host cell to release progeny virions. Double-stranded DNA phages typically promote host lysis using a holin-endolysin system. Holins form pores in the cytoplasmic membra...
Predictability of complex networks
We establish network predictability theory by mapping link prediction onto a spin glass model, where network partitions correspond to spin configurations, and predictability equals the system’s averag...
SypC: A symbiont morphogen packaged in bacterial vesicles
Efficient replication of influenza D virus in the human airway underscores zoonotic potential
Influenza D virus (IDV), primarily found in livestock species, has demonstrated cross-species transmission potential, yet its threat to humans remains poorly understood. Here, we curated a panel of ID...
Ensuring the future of Atlantic bluefin tuna
Atlantic bluefin tuna (ABT) are a highly migratory fish that have been exploited by fishers for more than two millennia. This lucrative fishery is managed by the International Commission for Conservat...
Smooth-to-rough morphotype alterations in <i>Mycobacterium abscessus</i> and their putative impact on phage resistance
Masculinization of populations reverses sex differences in fertility
Reproductive-age populations show a growing male surplus around the globe as a consequence of declining mortality, narrowing sex differences in mortality, and sex-selective abortions in some countries...
Failure of early B cell tolerance and possible BCR signaling dysregulation underlie NF155-mediated autoimmune nodopathies
Autoimmune nodopathies (AINs) are rare acquired autoimmune neuropathies with distinct clinical features and circulating autoantibodies, often of the immunoglobulin G4 (IgG4) subclass, targeting protei...
When energy is scarce, evolution selects dormancy
Dopaminergic modulation of the sense of agency influences moral behavior in Parkinson’s disease
Embodied accounts of morality propose that corporeal self-awareness helps restrain immoral actions. The Sense of Agency (SoA)—the feeling of controlling one’s actions and their consequences—drops when...
A farnesol-sensing triad in <i>Pseudomonas aeruginosa</i> drives interkingdom predation on <i>Candida albicans</i> via signal transduction
Microbial interactions, particularly bacteria–fungus interactions, are research hotspots within microbial ecology and pathogenic biology. However, their underlying molecular mechanisms remain poorly u...
Loss of UFL1 drives chromosome instability and tumorigenesis of prostate cancer
Chromosomal instability (CIN) is a prevalent form of genomic instability in prostate cancer (PCa). However, its molecular mechanisms remain inadequately understood. This study demonstrates that reduce...