Proceedings of the National Academy of Sciences
Articles in this Issue
Neural reservoir control of a bio-hybrid soft arm
A long-standing engineering problem, the control of soft robots is difficult because of their highly nonlinear, heterogeneous, anisotropic, and distributed nature. Here, bridging engineering and biolo...
Mapping fast tissue dynamics with long camera exposures via intensity modulation
Measuring fast dynamic processes with dynamic light scattering over wide fields of view is critical for applications ranging from blood flow imaging to characterizing complex fluids, yet is often limi...
Dual-channel event microscopy for ultrafast biological imaging
Many fundamental biological processes—spanning immune–tumor interactions, neuronal signaling, and microvascular flow—exhibit fast, multiscale dynamics among diverse cell types within three-dimensional...
From <i>Drosophila</i> to mammals: The evolutionarily conserved homeodomain protein Engrailed affects the antitumor innate immune response
In the process of investigating innate immune reactions against injected oncogenic cells in Drosophila , we noted that the homeodomain protein Engrailed, known...
Gagarinite-type Fe <sub>2.5</sub> (OH) <sub>6</sub> under the deep lower mantle conditions
Earth’s lower mantle is dominated by (Mg,Fe)SiO 3 bridgmanite. It was reported that (Mg,Fe)SiO 3 decomposes into an Fe-d...
Genome degradation in plant tissue culture
Many plants, unlike most animals, can reproduce as clones [D. Kester, HortScience 18 , 831–837 (1983), 10.21273/hortsci.18.6.831]. Cloning p...
Cumulative access to print books improves literacy achievement: Evidence from a five-year randomized trial in high-poverty schools
For more than a century, studies have shown that children who grow up in homes with more books achieve higher levels of academic success, yet it remains unclear whether books themselves improve learni...
Soil organic nitrogen rather than fertilizer drives dinitrogen losses in flooded rice systems
Rice production underpins food security but relies heavily on nitrogen (N) fertilization, much of which is lost as gaseous emissions. Dinitrogen (N 2 ) represen...
PMF proteins mediate mitochondrial fusion in Arabidopsis
Mitochondrial dynamics—continuous fission and fusion—are hallmarks of these organelles and essential for mitochondrial function across eukaryotes. While fission is relatively well understood in plants...
Mechanism of MutLβ-dependent DNA expansions
MutS and MutL proteins and their eukaryotic homologs have important functions in DNA metabolism. MutLβ (MLH1-PMS1 heterodimer) is a poorly understood eukaryotic MutL complex. Recent genetic studies ha...
Targeting CRTC2 reverses <i>STK11</i> mutant NSCLC tumor resistance to immunotherapy
Non–small cell lung cancer (NSCLC) patients with tumors harboring STK11 mutations are resistant to standard of care anti-PD-1/PD-L1 blockade. For this patient p...
Bipartisan-cited science is rare, unevenly distributed, and disproportionately influential
This study offers a systematic analysis of scientific papers cited in both Republican and Democratic policy documents. Using data from Overton and Dimensions, we examine congressional reports, hearing...
A simple threshold captures the social learning of conventions
A persistent puzzle throughout the cognitive and social sciences is how people manage to learn social conventions from the sparse and noisy behavioral data of diverse actors, without explicit instruct...
Structure of scientific knowledge flows to intergovernmental organizations
Intergovernmental organizations (IGOs) attempt to shape global policy through scientific guidelines and assessments. While they rely on external scientists to bridge research and IGO advisory processe...
Ice amplifies ligand-controlled mineral dissolution in microscale hot spots
Cold-region ecosystems are highly sensitive to climate change, yet the geochemical processes shaping their future remain poorly understood. Here, we show that ice systematically enhances mineral disso...
A magnesium efflux transporter required for seed development and eating quality in rice
As a staple food for half the world’s population, rice is an important dietary source of magnesium (Mg), an essential mineral for human health. Enhanced Mg accumulation in rice grains has also been li...
Learn from the blame game when AI causes harm
Transsynaptic linking of calcium channels and postsynaptic receptors at a dyadic synapse
Polyadic synapses (where each active zone is juxtaposed with multiple postsynaptic targets) are found in many brain regions and are implicated in learning and memory, yet little is known about how the...
Beyond gene duplication: A-to-I RNA editing–mediated stop codon readthrough modulates Dbf2 dosage to resolve pleiotropic conflicts
Stop codon readthrough is widespread across eukaryotes and often dismissed as translational noise, yet its tissue/stage-specific occurrence suggests adaptive roles in proteome tuning. We asked whether...