Proceedings of the National Academy of Sciences
Articles in this Issue
Human enterotoxigenic <i>Escherichia coli</i> (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic <i>Escherichia coli</i> and <i>Shigella</i>
Enterotoxigenic Escherichia coli (ETEC) and Shigella are the most common bacterial diarrheal pathogens among young child...
Lysosomal TMEM165 remodels calcium signaling to drive hypoxia adaptation and tumor progression
Hypoxia is a common stress encountered by animal tissues during development, physiology, and disease. To cope with hypoxic stress, cells remodel metabolic and signaling networks to preserve viability...
Scalable networks of multimodal haptic arrays for plantar sensory substitution
Feet provide essential sensory input, supporting body awareness for safe movement. The impairment of plantar sensation, arising in conditions such as stroke and spinal cord injury, has a major impact...
Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension
Schistosomiasis-associated pulmonary hypertension (Sch-PH) is the most common form of group I PH worldwide. Recently, data revealed that the preclinical Sch-PH animal model exhibited gut and lung micr...
Correction for Zhang et al., Deep learning framework for quantifying self-organization in <i>Myxococcus xanthus</i>
A pico-calorimeter for cellular metabolism and antimicrobial susceptibility testing
While methods exist to indirectly quantify the metabolism of biological systems, directly measuring metabolic rates in living samples remains challenging. Here, we describe a calorimetric sensor with...
A vast temporal continuum for sensory processing arises from a nontopographic cellular multilevel gradient
Classification of neurons into discrete populations aids the comprehension of neuronal function. However, such simplifications do not fully reflect the complexity and gradual nature of sensory stimuli...
Improved latitudinal carbon budgets from global airborne surveys
Robust information on the spatial distribution of global carbon fluxes is required to project the future trajectory of carbon-climate feedback effects and atmospheric CO 2...
Uncovering thousands of endosymbiont DNA transfer events within single cockroach genomes
Horizontal gene transfer (HGT) between organisms can be a valuable source of genetic variation and innovation. Research on HGT in eukaryotes has hitherto focused on transfers of coding sequences; inse...
Multidecadal preindustrial methane variability can be explained by noise in the source–sink imbalance
Ice core records of preindustrial methane indicate variability of ±...
Triggering three-step relay mechanism over Cu-based electrocatalysts for nitrate reduction
Electrocatalytic nitrate reduction reaction (NO 3 RR) is a promising approach for pollutant appreciation. Cu-based catalysts have attracted extensive attention...
Structural and cellular insights into DCTPP1 antagonists and their synergistic action with DNMT inhibitors
DCTPP1 is a nucleotide pyrophosphatase that helps preserve genomic stability and epigenetic programming by hydrolyzing and preventing the misincorporation of methylated base-modified deoxycytosine tri...
Revisiting dopamine function in cognition through abstract decision-making
Global decline in pollination limitation of pollinator-dependent crops
Biotic pollination benefits 75% of crops, representing about 35% of global food production. Given widespread reports of pollinator decline over the last decades, crop yield losses might be expected. H...
Forests shaped by historical human tragedies: Insights from Europe’s oldest angiosperms
ERK builds a population of short-lived nascent adhesions that produce persistent edge protrusion and cell migration
Cell migration is realized through the fast and persistent protrusion of a leading edge in the direction of movement. The actin and adhesion structures that build edge protrusions are integrated such...
Tuning reductase activity in monoterpene indole alkaloid biosynthesis
Monoterpene indole alkaloids encompass a diverse class of plant natural products. Many of these valuable compounds, including the anticancer medicines vinblastine and vincristine (...
Oxytocin modulates the neurocomputational mechanisms engaged in learning rank relationships in social networks
Indirect evidence from preclinical and neuropharmacological studies suggests that oxytocin may attenuate social dominance relationships and modulate social memory. In humans, oxytocin may also modulat...
ModBind <sub>dG</sub> : A simulation-based absolute predictor of free energy of binding based on population reweighting
Recently, we described ModBind, a powerful simulation-based predictor of ligand off-rates and binding free energy. Here, we describe an update to the method—ModBind dG...
The diversity of soil parasitic protists shapes ecosystem stability worldwide
Soil parasitic protists influence the health of plants and soil organisms. Yet, the extent to which these interactions impact the stability of terrestrial ecosystems remains largely unquantified. Here...
Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination
Mitochondrial endonuclease G (EndoG) is involved in several important cellular processes and has been implicated in multiple diseases. Accordingly, molecules modulating EndoG activity may have high th...
AI agents are sensitive to nudges
Large language models (LLMs) are increasingly deployed as autonomous agents that make choices and use tools on behalf of users. Yet, we have limited evidence about how their decisions are shaped by th...
<i>Drosophila</i> Myc ameliorates defects in mitochondrial homeostasis and muscle maturation caused by Metaxin-2 deficiency
Mitochondrial protein import machineries are essential for organelle homeostasis. Metaxin-2 (Mtx2) is an evolutionarily conserved component of the mitochondrial sorting and assembly machinery, and its...