Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Huang et al., A magnesium efflux transporter required for seed development and eating quality in rice
Misattributed biospheric carbon sink to the Three-North Program in the Taklamakan Desert may lead to an impractical policy: A commentary
Reply to Uma Shaanker: Pollen aggregations, genomic conflict, and single paternity in multiseeded fruits
Correction for Green et al., The intestinal microbiota impacts nutritional immunity and resistance to <i>Acinetobacter baumannii</i> pneumonia
Toward quantum sensing of electron beams using solid-state spins
Scattering experiments with energetic particles, such as free electrons, have been historically used to reveal the quantum structure of matter. However, realizing coherent interactions between free-el...
Sampling bias inflates claims of floral monogamy: A reassessment of Bawa et al. (2025)
Reply to Gao et al. and Xu: Greening the Taklamakan: Human efforts to convert desert into a carbon sink
Host genetic regulation of rumen 6-hydroxymelatonin reduces methane emissions in dairy cattle
The mechanisms linking host genetics to ruminal methane emissions remain unclear. Here, we integrated multiomics data from 304 lactating cows and demonstrated that methane emission per dry matter inta...
High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds
Chemical pollution is a global threat to human health, yet the toxicity mechanisms of most contaminants remains unknown. Here, we applied an ultrahigh-throughput affinity selection–mass spectrometry (...
Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment
Deterioration of the blood–brain barrier (BBB), including impaired neurovascular uncoupling, contributes to cognitive decline in aging. The BBB is formed principally by brain microvascular endothelial...
Spatial and temporal prediction of <i>Aedes aegypti</i> populations with atmospheric and urban forms dependence
Accurately predicting mosquito population dynamics in cities requires models that couple climatic sensitivity with urban spatial heterogeneity. We developed a spatially explicit, climate-driven framew...
Evolutionarily conserved and divergent mechanisms of dual Ca <sup>2+</sup> sensors in synaptic vesicle exocytosis
Neurotransmitter release at the Caenorhabditis elegans neuromuscular junction is governed by a dual Ca 2+ sensor system...
Koopman mode decomposition of thermodynamic dissipation in nonlinear Langevin dynamics
Nonlinear oscillations are commonly observed in complex systems far from equilibrium, such as living organisms. These oscillations are essential for sustaining vital processes, like neuronal firing, c...
Structural basis for lysophosphatidic acid recognition and atypical Gα <sub>q</sub> coupling by LPAR5
Lysophosphatidic acid receptor 5 (LPAR5) is a non-endothelial differentiation gene class A G protein–coupled receptor that regulates neuropathic pain, itch, and cancer progression through coupling to...
Overlap locking and nonperturbative effects in spin glasses
We study the phenomenon of the locking of the order parameter (or synchronization) in spin glasses at low temperatures. When two systems with independent disorders are coupled, their overlaps become s...
TFPI2 promotes NK cell–mediated glioblastoma killing through adhesion and checkpoint control
Immune-mediated killing triggers dynamic transcriptional adaptations in tumor cells that can reciprocally regulate the cytolytic process. Unraveling such feedback mechanisms is crucial for advancing c...
Collapsible scissored surfaces
We introduce an additive approach for the design of a class of transformable structures based on two-bar linkages (“scissor mechanisms”) joined at vertices to form a two-dimensional mesh which we call...
Binomial prolate spheroidal functions, Pascal matrices, and arithmetic of elliptic curves
The ( N + 1...
Targeting the DNA methylation–H3K27me3 switch reverses castration resistance and immunosuppression via ADAMTS1-driven collagenolysis
Castration-resistant prostate cancer (CRPC) lethality arises from epigenetic-driven resistance to androgen deprivation therapy (ADT). Here, we uncover a compensatory epigenetic switch between DNA meth...
Photoexcitation induces translocation of a common fluorescent pH and proton-transfer probe confined in reverse micelles
The photoacid 8-hydroxypyrene-1,3,6-trisulfonate (HPTS) is one of the most widely used fluorescent probes for studying proton transfer and local pH in systems from advanced materials to plants, enviro...
Video games help push the boundaries of AI
Genome-edited rice variety with low-cadmium accumulation in the grain
Cadmium (Cd) is a toxic and carcinogenic heavy metal, and rice, as a staple food, is a major source of dietary Cd intake. Therefore, limiting the transfer of Cd from soil to rice grain without comprom...
Persistent selection on size explains micro- and macroevolutionary alignments in fly wings
The alignment among mutational variance ( M ), standing genetic variance ( G ), and macroevolutionary divergence (...
Conformity to popular, not average, opinions: Models, data, and evolution
In assessing how individuals in a network estimate a quantity, it is often assumed that they take an average or weighted average of the estimates of others they observe, as in the French–DeGroot learn...
TL1A/DR3 signaling deletion attenuates mucosal inflammation and alveolar bone loss in a murine model of spontaneous periodontitis
TL1A and its receptor DR3 are key regulators of mucosal immune responses, but their role in periodontal disease is unknown. Herein, we investigated whether TL1A/DR3 signaling contributes to mucosal im...