Proceedings of the National Academy of Sciences
Articles in this Issue
Bacterial metabolism rather than necromass dominates input to soil organic carbon
Soil organic carbon (OC) sequestration is presumed to rely to a large extent on microbial transformation of plant residues into microbial necromass. Necromass formation, however, represents only one p...
A single brief cue leaves a day-long internal state imprint in planarians
Behavioral decisions are elicited by environmental stimuli, but they are critically modulated by internal states. Persistent state-dependent biases are typically attributed to accumulated sensory hist...
The ERAD pathway mediates cross talk between two control points in cholesterol synthesis: HMG CoA reductase and squalene monooxygenase
Two key enzymes, HMG CoA reductase (HMGCR) and squalene monooxygenase (SM), are subjected to distinct endoplasmic reticulum–associated degradation (ERAD) pathways to maintain cholesterol homeostasis....
Structural insights into RNA recognition by the <i>Staphylococcus aureus</i> exoribonuclease YhaM
Bacterial ribonucleases regulate gene expression in response to environmental stress and host interactions. In Staphylococcus aureus ,...
The physiological relevance of downstream effectors of p53 activity
The TP53 tumor suppressor encodes a transcription factor that regulates the expression of hundreds of target genes. Previous mouse studies have identified a con...
Canonical EDS1/PAD4 small-molecule binding sites are required for LRR-RP-mediated pattern-triggered immunity
Pattern-triggered immunity (PTI) is a key plant defense mechanism initiated by the recognition of pathogen-associated molecular patterns (PAMPs) by cell-surface receptors, including leucine-rich repea...
Epithelial cells fire voltage spikes
Bioelectric signaling is well characterized in neurons and cardiomyocytes but remains largely unexplored in epithelia. Using multielectrode arrays, we demonstrate that localized laser injury to epithe...
Correlated gene copy number changes in a seminal fluid protein network in <i>Drosophila</i>
In Drosophila melanogaster , the male seminal fluid protein Sex Peptide regulates persistent postmating changes in female physiology and behavior. The persisten...
Restoring the interplay between the endoplasmic reticulum and mitochondria by gene therapy improves Charcot–Marie–Tooth type 2A disease
Charcot–Marie–Tooth disease type 2A (CMT2A) is the most common axonal CMT and is associated with an early onset and severe motor neuropathy. CMT2A is mainly caused by dominant mutations in the...
Diminished transcriptional activity and splicing changes drive gene length–biased rewiring in the aging transcriptome
Transcription by RNA polymerase II (RNAPII), which is essential for protein-coding gene expression and cellular function, is increasingly understood to become dysregulated with aging. Here, we use a m...
Correction for Lollar and Warr, Decadal record of continental H <sub>2</sub> reservoirs reveals potential for subsurface microbial life and natural H <sub>2</sub> exploration
The global diversity and decline of glacier animals
Glacier environments host an unrecognized number of animals that are at high risk of extinction due to global warming. Yet, the absence of comprehensive analyses has hampered the development of a coor...
A cannabidiol-sensitive region involved in the allosteric modulation of the α7 nicotinic receptor
Cannabidiol (CBD), a nonpsychoactive phytocannabinoid from Cannabis sativa , modulates the α7 nicotinic acetylcholine receptor (α7 nAChR), a key target in neuro...
Polycatechol-based iron predators disrupt fungal iron homeostasis to drive selective antifungal action
Fungal infections pose a growing global health challenge, exacerbated by a scarcity of effective treatments and rising drug resistance. Although cationic polymers emerge as promising antifungal candid...
Regulatory logic underlying neural crest contributions to the head versus the heart
Neural crest cells exhibit axial-level-specific transcriptional programs, yet the regulatory mechanisms underlying their fate decisions remain unclear. Here, we investigate whether differential transc...
Accounting for uncertainty and bias in archaeological and historical evidence on wealth inequality
The archaeological and historical record allows us to study the patterns of economic inequalities associated with sharply contrasting institutions such as communal property in societies without states...
Actuation driven pseudocrease mechanics in multistable curved-crease origami shells
Shells are lightweight load-bearing structures found ubiquitously throughout nature and engineering. Reconfigurable structures can change form and function, while multistable ones enable fast, large s...
Sweet and fatty symbionts: Photosynthetic productivity and carbon storage boosted in microalgae within a host
Symbiosis between a host and intracellular eukaryotic microalgae is a widespread life strategy in aquatic ecosystems. This partnership is considered to be mainly energized by the supply of photosynthe...
Genome-wide analysis of mRNA regionalization in a giant single cell
The molecular mechanisms that produce cell structure are poorly understood. The giant ciliate Stentor coeruleus is a unicellular model organism whose large size...
Correction for De Anda et al., The archaeal roots of eukaryotic life
Catch, dock, unravel, and lock
Scent and adhesion drive insect dispersal of environmental yeast
Insects and terrestrial fungi have lived on planet earth together for over 400 My. Different insect species are commonly associated with distinct mycobiomes. These insect–fungal associations are thoug...
Fractional charge density functional theory elucidates electro-inductive and electric field effects at electrochemical interfaces
The application of external voltages to self-assembled monolayers formed on electrodes allows for dynamic tuning of the properties of the constituent molecules. The electrode and the applied voltage g...
Random-with-constraints: Constructing minimal models for high-dimensional biology
Biologists and physicists have a rich tradition of modeling dynamics of living systems with simple models composed of a few interacting components. Despite the remarkable success of this approach, it...
The EMB/ATG7-mediated autophagic process regulates neurite outgrowth and promotes enteric neuronal development
The formation of the enteric nervous system (ENS) primarily involves the migration of enteric neural crest-derived cells (ENCCs) and the subsequent maturation of enteric neurons. The developmental dys...