Proceedings of the National Academy of Sciences
Articles in this Issue
Proviral insights of glycolytic enolase in <i>Bamboo mosaic virus</i> replication associated with chloroplasts and mitochondria
Diverse single-stranded RNA viruses employ different host cellular organelles or membrane systems to compartmentalize their replication intermediates and proviral factors, ensuring robust replication....
Interspecies interactions in dual, fibrous gels enable control of gel structure and rheology
Natural and synthetic multicomponent gels display emergent properties, which implies that they are more than just the sum of their components. This warrants the investigation of the role played by int...
Cross-feeding creates tipping points in microbiome diversity
A key unresolved question in microbial ecology is how the extraordinary diversity of microbiomes emerges from the interactions among their many functionally distinct populations. This process is drive...
Population imaging of enterochromaffin cell activity reveals regulation by somatostatin
Sensory enteroendocrine cells in the intestinal epithelium detect and relay information about the luminal environment to other cells within and outside the gut. Serotonergic enterochromaffin (EC) cell...
De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease
Infiltrating neutrophils are key effector cells in inflammatory bowel disease (IBD) while providing antimicrobial defense and tissue restitution in the intestine. The complexity of neutrophil function...
METTL3 mediates atheroprone flow–induced glycolysis in endothelial cells
Atheroprone flow–increased glycolysis in vascular endothelial cells (ECs) is pivotal in EC dysfunction and the initiation of atherosclerosis. Methyltransferase 3 (METTL3) is a major m...
Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography
Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficul...
Methodological and conceptual considerations of the TCM evolution
Phylogenomics of the tetraploid Hawaiian lobeliads: Implications for their origin, dispersal history, and adaptive radiation
Hawaiian lobeliads exhibit extensive adaptive radiations and are considered the largest plant clade (143 species) endemic to any oceanic archipelago. Rapid insular radiations are prone to reticulate e...
Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia
How central and peripheral circadian clocks regulate protein metabolism and affect tissue mass homeostasis has been unclear. Circadian shifts in the balance between anabolism and catabolism control mu...
Loss of lipid asymmetry facilitates plasma membrane blebbing by decreasing membrane lipid packing
Membrane blebs have important roles in cell migration, apoptosis, and intercellular communication through extracellular vesicles (EVs). While plasma membranes (PM) typically maintain phosphatidylserin...
Paradoxical indeed
Eat, flee, freeze: Division of labor in the larval zebrafish visuomotor system
Simulating regional workforce impacts of decarbonizing integrated steelmaking
Global efforts to mitigate climate change are increasing pressure on heavy manufacturing industries to decarbonize production. The iron and steel industry is responsible for 7% of CO...
Pre-Hispanic ritual use of psychoactive plants at Chavín de Huántar, Peru
Ritual is broadly accepted as an important locus of social interaction in the pre-Hispanic Central Andes, and research into the development of durable sociopolitical inequality in the region often foc...
Reply to Wang and Wang: Exploring TCM evolution from the perspective of recombinant inventions and the data
Early development of navigationally relevant location information in the retrosplenial complex
Representing the locations of places so that we can use them as landmarks is critical to our ability to navigate through large-scale spaces—a process referred to as “map-based navigation.” While many...
Distinguishing species boundaries from geographic variation
In an era of unprecedented biodiversity loss, the need for standardized practices to describe biological variation is becoming increasingly important. As with all scientific endeavors, species delimit...
Refining the role of the paraventricular hypothalamus in feeding behavior
Reply to Compton et al.: Paradoxical misunderstanding
The SIK3-N783Y mutation is associated with the human natural short sleep trait
Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep duration and depth in rodents, is associated with natural s...
Prioritizing urban heat adaptation infrastructure based on multiple outcomes: Comfort, health, and energy
Globally, cities face increasing extreme heat, impacting comfort, health, and energy consumption. Infrastructure-based heat adaptation strategies can improve these outcomes, but each strategy has a un...
miR218-5p tips the scales
Lateral jaw motion in fish expands the functional repertoire of vertebrates and underpins the success of a dominant herbivore lineage
The primary function of the vertebrate jaw is the dorsoventral movement that occurs during opening and closing. Yet, several lineages have evolved the ability to move their jaws laterally, enabling ma...
Cortical signatures linked to behavior quantitatively track arousal levels
While current arousal level assessments in patients with disorders of consciousness discriminate altered states of consciousness, there are significant limitations in characterizing the transition fro...