Proceedings of the National Academy of Sciences
Articles in this Issue
Exploiting thioether reactivity to label mycobacterial glycans
Mycobacterium tuberculosis ( Mtb ) is a leading cause of death worldwide. Mtb cell envelope glycans...
Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus
We have generated a single-cell RNA sequencing atlas of peripheral blood and ventricular CSF in idiopathic normal pressure hydrocephalus (iNPH) patients totaling 140,207 single-cell transcriptomes. We...
Activity and structure of human (d)CTP deaminase CDADC1
Vertebrates have evolved an understudied protein termed CDADC1 (NYD-SP15) that contains an inactive N-terminal and active C-terminal DCTD-like domain. Here, we show that human CDADC1 is a (d)CTP-speci...
Structure and nucleic acid interactions of the S <sup>Δ60</sup> domain of the hepatitis delta virus small antigen
Infection with hepatitis delta virus (HDV) causes the most severe form of viral hepatitis, affecting more than 15 million people worldwide. HDV is a small RNA satellite virus of the hepatitis B virus...
Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut
Biodegradable polylactic acid (PLA) plastics have been praised as an effective solution to the global pollution caused by petroleum-based plastics, and their widespread use in food packaging and dispo...
Dynamic interplay between niche variation and flight adaptability drove a hundred million years’ dispersion in iconic lacewings
The form and change of animal biogeography reflects the long-term interplay between organisms and their environment, involving physiological limitation, dispersal capability, and adaptive evolution ve...
Accurate, scalable, and fully automated inference of species trees from raw genome assemblies using ROADIES
Current genome sequencing initiatives across a wide range of life forms offer significant potential to enhance our understanding of evolutionary relationships and support transformative biological and...
Why does AI hinder democratization?
This paper examines the relationship between democratization and the development of AI and information and communication technology (ICT). Our empirical evidence shows that in the past 10 y, the advan...