Proceedings of the National Academy of Sciences
Articles in this Issue
Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia
Spreading depolarizations (SDs) have been identified in various brain pathologies. SDs increase the cerebral energy demand and, concomitantly, oxygen consumption, which indicates enhanced synthesis of...
Circadian clock–gated cell renewal controls time-dependent changes in taste sensitivity
Circadian regulation of the cell cycle progression generates a diurnal supply of newborn cells to replace those lost in organs and tissues. In this study, we analyzed circadian time-dependent changes...
Distinct latitudinal patterns of molecular rates across vertebrates
The latitudinal diversity gradient (LDG) is the most notable global biodiversity pattern, but its underlying mechanisms remain unresolved. The evolutionary speed hypothesis (ESH) posits that molecular...
In silico machine learning–enabled detection of polycyclic aromatic hydrocarbons from contaminated soil
The detection and identification of polycyclic aromatic hydrocarbons (PAHs) and their modified derivatives in contaminated soil is challenging due to the chemical and microbial complexity of soil orga...
Amplification mechanism with interacting atomic gases
The use of atoms, molecules, and free electrons in quantum amplifiers has greatly advanced precision measurements, paving the way for the development of extremely-low-noise quantum devices such as mas...
Molecular insights into de novo small-molecule recognition by an intron RNA structure
Despite the promise of vastly expanding the druggable genome, rational design of RNA-targeting ligands remains challenging as it requires the rapid identification of hits and visualization of the resu...
The oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity
Cancer cells frequently reprogram one-carbon metabolic pathways to fulfill their vigorous demands of biosynthesis and antioxidant defense for survival and proliferation. Dysfunction of oncogenes or tu...
Persistent pseudopod splitting is an effective chemotaxis strategy in shallow gradients
Single-cell organisms and various cell types use a range of motility modes when following a chemical gradient, but it is unclear which mode is best suited for different gradients. Here, we model direc...
DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis
Vascular development is a precisely controlled process, yet how it is spatiotemporally orchestrated remains enigmatic. We previously identified DEAD-box RNA helicase 24 (DDX24) as a pathogenic gene fo...
Observation of disorder-induced boundary localization
Bloch wavefunctions in crystals experience localization within the bulk when disorder is introduced, a phenomenon commonly known as Anderson localization. This effect is considered universal, being ap...
Evidence of a social evaluation penalty for using AI
Despite the rapid proliferation of AI tools, we know little about how people who use them are perceived by others. Drawing on theories of attribution and impression management, we propose that people...
NF-κB-mediated developmental delay extends lifespan in <i>Drosophila</i>
Developmental time (or time to maturity) strongly correlates with an animal’s maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phen...
Hdac1 as an early determinant of intermediate-exhausted CD8 <sup>+</sup> T cell fate in chronic viral infection
The exhausted CD8 + T (T EX ) cells consist of distinct subsets including Tcf1 +...
Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers
Heterotrimeric Gα:Gβγ G proteins function as molecular switches downstream of G protein–coupled receptors (GPCRs). They alternate between a heterotrimeric GDP-bound OFF-state and a GTP-bound ON-state...
Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses
Yellow fever vaccination provides long-lasting protection and is a unique model for studying the immune response to an acute RNA virus infection in humans. To elucidate the early innate immune events...
We need better ways to re-evaluate conservation policies when they’re founded on flawed research
Improved synapsis dynamics accompany meiotic stability in <i>Arabidopsis arenosa</i> autotetraploids
During meiosis, the correct pairing, synapsis, and recombination of homologous chromosome pairs is critical for fertility of sexual eukaryotes. These processes are challenged in polyploids, which poss...
Intercellular contractile force attenuates chemosensitivity through Notch-MVP-mediated nuclear drug export
Resistance to chemotherapeutics is one major challenge to clinical effectiveness of cancer treatment and is primarily interpreted by various biochemical mechanisms. This study establishes an inverse c...
Healthy sleep durations appear to vary across cultures
Past research finds that sleep duration is reliably linked with health yet sleep durations differ substantially between countries. We investigated whether countries with shorter sleep durations have w...
Monsoon hysteresis reveals atmospheric memory
Within Earth’s climate system, the ocean, cryosphere, and vegetation exhibit hysteresis behavior such that their state depends on their past and not merely on their current boundary conditions. The at...
Mechanism and application of thiol–disulfide redox biosensors with a fluorescence-lifetime readout
Genetically encoded biosensors with changes in fluorescence lifetime (as opposed to fluorescence intensity) can quantify small molecules in complex contexts, even in vivo. However, lifetime-readout se...
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex
PARK7/DJ-1, a redox-sensitive protein implicated in neurodegeneration, cancer, and inflammation, exhibits increased secretion under stress. We previously demonstrated that, as a leaderless protein, PA...
Conversion of social organization in fire ants induced by few colony members: Unmasking indirect genetic effects
Genes and the environment jointly shape individual traits, but the influence of indirect genetic effects (IGEs), arising from the genetic composition of interacting conspecific individuals, is often i...
Combining live fluorescence imaging with in situ cryoelectron tomography sheds light on the septation process in <i>Deinococcus radiodurans</i>
Cell division is a fundamental biological process that allows a single mother cell to produce two daughter cells. In walled bacteria, different modes of cell division have been reported that are notab...
Paving the way for social touch at a distance: Sonifying tactile interactions and their underlying emotions
Social touch is crucial for human well-being, as a lack of tactile interactions increases anxiety, loneliness, and need for social support. To address the detrimental effects of social isolation, we b...