Proceedings of the National Academy of Sciences
Articles in this Issue
Allosteric gating of radical transport in ribonucleotide reductase
High bacterial diversity drives the suppression of a soilborne plant disease
The rhizosphere microbiome plays a crucial role in the resistance to soilborne plant diseases. However, the principles needed to explain and predict which microbiota will be effective against soilborn...
Cellular circadian period and its deviation associate with Alzheimer’s pathology and brain aging in cognitively impaired older adults
Circadian rhythm disruption is recognized as a feature of aging and neurodegenerative disease, yet whether intrinsic cellular circadian properties relate to underlying processes in humans remains unkn...
Rapid solar energy development in deserts: A missing element in desertification control and achieving Sustainable Development Goals
Persistent adaptation through dual-timescale regulation of ion channel properties
Neurons are terminally differentiated cells that adapt to maintain stable function over years, despite encountering a wide range of environmental perturbations. In some cases, recovery from perturbati...
Oxidized Hadean magmas and Archean mobile-lid tectonics revealed by Jack Hills zircon
Mobile-lid tectonics is a first-order feature characterizing the modern Earth, yet its origins remain enigmatic due to a scarcity of ancient terrestrial materials. Detrital zircons provide the most co...
Saturation of superconductivity in cuprates overdoped with high-pressure oxygen: Phase diagram with YBa <sub>2</sub> Cu <sub>3</sub> O <sub>7+δ</sub> , δ → 1
High temperature superconductivity (HTSC) typically occurs as a “dome” over a narrow range of doping in its phase diagram. The reaction of YBa 2 Cu...
Competing like cats and dogs: Cougars lose their hard-won prey to wolves
Maya Postclassic persistence in the Birds of Paradise Wetland Fields, Belize
Rapid decay of organic artifacts obscures our view of ancient tropical settlements. We present a study of architecture and artifact assemblages from an ancient settlement excavated at the Birds of Par...
The persistence of potential: The life of Sir John B. Gurdon
The death of Sir John Bertrand Gurdon in October 2025 marks the passing of one of the most influential biologists of the modern era. A developmental biologist, Sir Gurdon’s best-known experiments were...
Thirty years of glacier grounding line retreat in Antarctica
The Grounding Line (GL)—the transition from ice grounded on the continent and ice afloat in the ocean—is a sensitive indicator of glacier stability and mass balance. Using differential synthetic apert...
Data deficiency, taxonomic bias, and economic interests curtail insect and arachnid conservation in the United States
Earth is experiencing a biodiversity crisis. Among the declining taxa are insects and arachnids, which account for most of the world’s animal species, and are ecologically and economically vital. Thus...
Coevolution of RNase P and the ribosome
Translation is carried out by the most conserved assemblies in biology. Among these assemblies, the ribosome and RNase P are central players. These ancient ribonucleoprotein complexes achieved structu...