Proceedings of the National Academy of Sciences
Articles in this Issue
Wild vegetables contribute to improving the diversity and sustainability of vegetable diets in China
Vegetables are vital to human diets, supplying essential micronutrients critical to overall health. Despite this, it remains unclear whether current supply systems effectively ensure equitable access...
HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression
Integration of the high-risk human papillomavirus 16 (HPV16) genome into the host chromosome, frequently driven by microhomology-mediated end joining (MMEJ), is a critical step in the carcinogenesis o...
ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering
Dendritic cell (DC) migration is critical for initiating adaptive immune responses. Previous work suggested a role for ATP-binding cassette transporter C1 (ABCC1) in skin DC migration following cutane...
A theoretical index for understanding distinct land relative humidity trends in observations, reanalyses, and models
Land surface relative humidity (RH) is a key variable in the coupled land–atmosphere system that profoundly influences terrestrial hydroclimate and ecosystems. Yet historical changes in land RH are no...
Loss of function of the chromatin remodeling gene <i>INO80D</i> leads to neurogenic features of schizophrenia
Schizophrenia has been linked to severely damaging de novo mutations in synaptic junction proteins, neurotransmitter receptors, transcription factors, and chromatin remodeling proteins. In a patient w...
Direct evidence of acid-driven protein desolvation
Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions. However, how amino acid protonation alters protein...
Disruption of a selective vesicle pool upon retrograde amnesia dissociates memory at presynaptic terminals
A single learning episode induces both labile and consolidated forms of aversive olfactory memory in Drosophila melanogaster...
Reactivation of the silenced <i>BASP1</i> gene suppresses oncogenic WNT signaling in human colorectal cancer cells
Starting from human colon cancer cells showing aberrant WNT/β-catenin/TCF signaling, hyperactivated MYC, and silenced BASP1...
Observed universal continuum morphology of raindrops reveals a concise diagram of heavy precipitation microphysics
Persistent knowledge gaps in precipitation microphysics, particularly the nonlinear coupling between microphysical process hierarchies and raindrop size distribution (DSD) variability, keep introducin...
Convolutional neural networks outperform other presence-only species distribution modeling algorithms
Species distribution models (SDMs) are essential tools for ecologists and conservationists because they can identify environmental determinants of species occurrences and predict species distributions...
The <i>DELAYED ABAXIAL TRICHOMES</i> Helitron has dual functions in vegetative and pollen development in <i>Arabidopsis thaliana</i>
Transposons drive genetic diversity and evolution by altering the genomic landscape over time. Here, we describe D ELAYED AB...
Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses
Recombinant adeno-associated viruses (rAAVs) are widely used for in vivo gene delivery. While KIAA0319L, known as AAV receptor (AAVR), is essential for the transduction of multiserotype AAVs, it is di...
MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer
MYC amplification contributes to poor survival and outcome in pancreatic ductal adenocarcinoma (PDAC). Here we show that in PDAC cell lines with amplified MYC, MondoA is required for viability, facili...
Correction for Eames et al., Computer-assisted learning in the real world: How Khan Academy influences student math learning
N6-methyladenine DNA modification modulates pathogen virulence in nematodes
Understanding the global regulatory mechanisms that control pathogen virulence gene expression is essential for elucidating the molecular basis of pathogenicity. N6-methyladenine (6 mA) plays a crucia...
Correction for Yu, Addressing the broader implications of AI–AI bias in decision-making systems
Five decades of seasonal phytoplankton succession examined with principal traits—An approach linking composition to function
Understanding how changes in community composition and function are driven by environmental change remains a fundamental challenge—to which trait-based approaches offer a mechanistic perspective. To e...
Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress
The mitochondrial unfolded protein response (UPR mt ) is triggered by cells to alleviate proteotoxicity in response to metabolic stress. The ability to anticipa...
Correction for Cho et al., Resilient tree-planting strategies for carbon dioxide removal under compounding climate and economic uncertainties
Moral stereotyping in large language models
Can Large Language Models (LLMs) accurately estimate various societies’ moral values? Here, we query the perceptions of LLMs regarding the moral norms of the “average” person from 48 nations and compa...
EIF4H and YBX1 are essential host factors for hepatitis E virus replication and pathogenesis
Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide, responsible for approximately 20 million infections annually. Despite the availability of a vaccine in China, no direct-a...
Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling
Self-association by small GTPases on membrane is critical for their signaling output and cellular function. However, a mechanistic understanding of how membrane components regulate this process remain...
Probing the microscopic origin of toughness in multiple polymer networks
Multiple polymer networks, such as double-network elastomers comprising a sacrificial and a matrix network, exhibit exceptional mechanical resilience, commonly attributed to the formation of an extend...
Nine changes needed to deliver a radical transformation in biodiversity measurement
Biodiversity is declining in many parts of the world. Biological diversity measurement and monitoring are fundamental to the assessment of the causes and consequences of environmental changes, identif...