Proceedings of the National Academy of Sciences
Articles in this Issue
PARP7 protects the lung epithelial barrier from diverse environmental threats
Poly-ADP-ribose polymerase (PARP) family proteins are involved in a wide range of cellular processes. Several PARPs are targeted by inhibitors as treatments for cancer based on their biochemical funct...
Correction for Xie et al., Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins
Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance
Glucocorticoids (GCs) are potent immunosuppressive agents that compromise anticancer immune responses, yet the molecular mediators of this effect remain incompletely understood. Here, we identify the...
Correction for Meireles et al., Aging populations threaten conservation goals of zoos
What’s the science behind acupuncture?
Repetitions trigger illusory awareness in implicit statistical learning
The present study examined the accuracy of conscious representations that emerge from implicit statistical learning (ISL), a fundamental cognitive process through which we extract regularities in the...
How to quantify immigration from community abundance data using the neutral community model
Biological communities are connected through dispersal, which regulates diversity across local and regional scales. However, dispersal is difficult to measure directly, limiting what is known about di...
NMI promotes the secretion of IL-17 and exacerbates psoriasis
Damage-associated molecular patterns (DAMPs) are well established as key mediators of innate immune activation; however, their functions in modulating adaptive immunity, particularly T cell responses,...
Coupled machine learning–ecosystem ensemble models substantially improve predictions of nitrous oxide (N <sub>2</sub> O) fluxes from US croplands
Nitrous oxide (N 2 O) is a potent and persistent greenhouse gas, with rising atmospheric concentrations driven in part by inefficient use of synthetic nitrogen...
Med14 phosphorylation shapes genomic response to GLP-1 agonists
Binding of GLP-1 to its receptor in pancreatic beta cells triggers activation of the cAMP pathway and phosphorylation of CREB, leading to induction of cellular target genes containing CREB binding sit...
Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint
Mechanoresponsive cell proliferation is a feature of growing tumors, despite the suppression of many other regulatory checkpoints in cancer, but the underlying cell-scale mechanisms driving this behav...
Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis
Hemolysis is associated with the release of damage-associated molecular patterns, including free heme and extracellular DNA (ecDNA). Using several mouse models of bleeding anemia and hemolysis, we dem...
Correction for Cheng and Yu, Integrating generative AI and physical tests to strengthen claims about emergent phenomena
Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates
FicD regulates Unfolded Protein Response (UPR) through reversible AMPylation and deAMPylation of BiP, an HSP70 chaperone and master regulator of the UPR. FicD activity is regulated by endoplasmic reti...
Bias in the AlphaFold3 prediction of ligand-induced domain motion in enzymes
In many enzymes, movement of domains from open to closed state forms the environment required for catalysis. We have studied ligand-induced domain motion in 82 enzymes by generating ensembles of Alpha...
Ultrasound-driven mechanophore activation in living plants
This study presents a biocompatible, ultrasound-responsive platform for remotely activating mechanochemical reactions within live plant tissue. Fluorogenic Mechanophore-embedded silica NanoParticles (...
From data to decisions: Toward a Biodiversity Monitoring Standards Framework
Achieving the goals of the Kunming–Montreal Global Biodiversity Framework (GBF) requires monitoring systems that can transform heterogeneous observations into consistent, decision-relevant knowledge....
Mechanical compliance enhances the impulsive energy absorption of glassy polymer films
From soft tissues to seismic damping systems, mechanical compliance is widely exploited by natural and engineered systems for dissipating energy and averting catastrophic failure. While this principle...
Correction for Yanaka et al., Exploring glycoform-dependent dynamic modulations in human immunoglobulin G via computational and experimental approaches
The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation
The human adenosine A 2A receptor (A 2A R) is a prototypical member of the class A family of G Protein–Coupled Receptors...
A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory
Understanding how brain-wide neural circuits are genetically wired remains a fundamental question in neuroscience. While Sperry’s chemoaffinity theory [Sperry, Proc. Natl. Acad. Sc...
Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy
The neuronal K/Cl cotransporter KCC2 regulates the transmembrane chloride gradient, which controls the efficacy of GABAergic signaling. In mesial temporal lobe epilepsy (mTLE) and other neurological d...
SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study
Synaptic loss is increasingly recognized as a key pathological feature in multiple sclerosis (MS), contributing to disease progression and cognitive dysfunction. Synaptic vesicle glycoprotein 2A (SV2A...
Global analysis of protein degradation reveals instability of diverse regulators in <i>Escherichia coli</i>
Regulated protein degradation underlies the timely execution of essential gene expression programs in bacteria. Here, we deployed time-resolved chemoproteomics, text mining of the PubMed and EcoCyc kn...
A BRI1–CNGC12 phosphorylation module links hormone signaling to manganese homeostasis in plants
Manganese (Mn) toxicity in acidic or waterlogged soils severely impacts crop productivity. Although high-Mn stress triggers Ca 2+ signals that regulate Mn homeo...