Proceedings of the National Academy of Sciences
Articles in this Issue
DNA methylation in invertebrate genomes and cell lineage plasticity
The extent of DNA methylation varies widely across animal genomes, from almost undetectable levels in some taxa to high, pervasive methylation in others. Although DNA methylation has been linked to ge...
The private solution trap in collective action problems across 34 nations
Collective action problems emerge when individual incentives and group interests are misaligned, as in the case of climate change. Individuals involved in these problems are generally considered to ha...
Correction for Fernández et al., Transcranial magnetic stimulation to frontal but not occipital cortex disrupts endogenous attention
Liquid anomalies and fragility of supercooled antimony
Phase-change materials (PCMs) based on group IV, V, and VI elements, such as Ge, Sb, and Te, exhibit distinctive liquid-state features, including thermodynamic anomalies and unusual dynamical properti...
Quantitative system drift
We consider a biological system composed of multiple genetically variable components, the combined result of which is a quantitative trait under stabilizing selection for an optimal value. We show mat...
Identification of somatostatin <sup>+</sup> inhibitory engrams for extinction in the basolateral amygdala
The basolateral amygdala (BLA) is a key structure for processing threat and emotional information, and plays a key role in controlling the fear memory. Previous research has suggested that the extinct...
Young children understand how social connections affect what people know about each other
An unwritten expectation in our everyday social interactions is that intimate personal information about someone—“insider knowledge”—is usually confined within close relationships. For example, it wou...
Task-evoked functional connectivity exhibits novel and strengthened relationships with executive function relative to the resting state
Executive functioning in children has been linked to intrinsic brain network organization assessed during the resting state, as well as to brain network organization during the performance of cognitiv...
Insights into cephalochordate genome and gene evolution from the early-diverging amphioxus <i>Asymmetron lucayanum</i>
Cephalochordates (amphioxus or lancelet) are considered as living proxies for ancestral chordates due to their key phylogenetic position and slow evolutionary rate. The genomes of living amphioxus thu...
Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade
Small cell carcinoma is a highly lethal cancer variant often found with neuroendocrine (NE) features, as exemplified by small cell lung cancer and small cell NE prostate cancer (SCPC). A genome-wide C...
Correction for Ghimenti et al., Clever algorithms for glasses work by time reparameterization
Spatially structured inflammatory response in the presence of a uniform stimulus
Inflammatory responses occur within the complex spatial context of tissues and organs, and many questions remain about how tissue structure and cellular communication shape their spatiotemporal dynami...
Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model
Primary cell culture is fast becoming a dominant method for discovery work regarding human disease. Currently, there are no methods to quantitatively benchmark these systems. Here, we apply a uniform...
Autogenic spinal excitatory circuit ensures skilled hand movements in primates
Skillful hand movements are a hallmark of primates, including humans, requiring sophisticated motor planning and execution. Building on the well-established cortical basis of dexterous control, our fi...
Invariant dual mechanics of tensegrity and origami
Statics and kinematics are often viewed as intertwined branches of mechanics. The principle of virtual work indicates this interconnection: For a system in static equilibrium, the total work performed...
Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil–vascular endothelial cell interactions
The acute inflammatory response is a highly coordinated programmed sequence that enables neutrophils to transmigrate from venules into tissues. Ideally self-limited, the active resolution phase produc...
A DNA-encoded recipe to direct multistage colloidal assembly
In equilibrium self-assembly, microscopic building blocks spontaneously self-organize into stable structures as dictated by their interaction potentials, which limits the accessible structural feature...
Photoreceptor control of <i>Platynereis</i> growth and lifespan via evolutionarily conserved molecular pathways
Natural light is severely affected by human impact on Earth, yet little is known about the roles light receptors have outside vision and rhythmic processes, despite their tremendously wide abundance....
Dynamic anticounterfeiting and tunable lasing with screen-printed cholesteric liquid crystal elastomers
Structural colors hold significant application value in anticounterfeiting, displays, and smart coatings due to their high stability, eco-friendliness, and dynamic optical response potential. However,...
The cross-linking activity of transglutaminase 2 drives α-Synuclein pathology in synucleinopathy models
Transglutaminase 2 (TG2) is implicated in synucleinopathies including Parkinson’s disease (PD) and dementia with Lewy bodies, as it promotes α-Synuclein (α-Syn) aggregation in vitro, and evidence for...
Phosphorus enrichment does not enlarge the predicted CO <sub>2</sub> fertilization effect on forest carbon sequestration
The capacity of nutrient-limited forests to enhance carbon (C) sequestration under elevated CO 2 (eCO 2 ) remains a crit...
SUN5 forms a regular protein lattice reinforcing the sperm head–tail junction
Spermatozoa strongly rely on their streamlined morphology to successfully fertilize an oocyte. A striking example of a morphological defect resulting in infertility is acephalic spermatozoa syndrome,...
Powers of magnetic graph matrix: Fourier spectrum, walk compression, and applications
Magnetic graphs, originally developed to model quantum systems under magnetic fields, have recently emerged as a powerful framework for analyzing complex directed networks. Existing research has prima...
Atomic-level architecture and assembly mechanism of high-order structures of RIPK1 fibril revealed by integrated structural biology
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) regulates cell death pathways through RHIM domain–mediated amyloid fibril formation. While amyloid fibrils typically exist as single fila...
Gut microbe–derived <i>N</i> -acyl serinol lipids shape host postprandial metabolic homeostasis
Although strong evidence links the gut microbiome to metabolic disease, the mechanisms linking microbiota to hormonal and metabolic responses to food are not well understood. After a meal, gut bacteri...