Gut microbe–derived <i>N</i> -acyl serinol lipids shape host postprandial metabolic homeostasis
Abstract
Although strong evidence links the gut microbiome to metabolic disease, the mechanisms linking microbiota to hormonal and metabolic responses to food are not well understood. After a meal, gut bacteria produce a wide array of small molecule, protein, and lipid metabolites originating from bacterial sources. Attributing physiological function to select gut microbe–derived metabolites is critical to understanding diet–microbe–host interactions, and to developing microbiome-inspired therapies to improve human health. Here, we have investigated the role of a poorly annotated class of gut microbiome-derived lipids called N -acyl amides in postprandial metabolic physiology. Here, we show that both bacterial production and provision of exogenous N -acyl amides reorganize host hormone-driven metabolic transition after a meal. Moreover, N -acyl amides exert broad effects on the meal- and circadian-related reorganization of gene expression, metabolic hormones, and gut microbiome composition. Collectively, these results demonstrate that microbiota-derived N -acyl amides play a physiologic role in postprandial metabolic homeostasis in the host.
Article Details
Journal Info
Proceedings of the National Academy of Sciences
National Academy of Sciences
Authors (29)
Sumita Dutta
Department of Microbial Sciences in Health, Cleveland Clinic Research
Kala K. Mahen
Department of Microbial Sciences in Health, Cleveland Clinic Research
William J. Massey
Department of Inflammation and Immunity, Cleveland Clinic Research
Venkateshwari Varadharajan
Department of Microbial Sciences in Health, Cleveland Clinic Research
Amy C. Burrows
Department of Microbial Sciences in Health, Cleveland Clinic Research
Anthony J. Horak
Department of Microbial Sciences in Health, Cleveland Clinic Research
Marko Mrdjen
Department of Microbial Sciences in Health, Cleveland Clinic Research
Nour Mouannes
Department of Microbial Sciences in Health, Cleveland Clinic Research
Danny Orabi
Center for Microbiome and Human Health, Cleveland Clinic Research
Lucas J. Osborn
Department of Heart, Blood, and Kidney Research, Cleveland Clinic Research
Treg Grubb
Department of Cancer Sciences, Cleveland Clinic Research
Rachel C. Hohe
Department of Microbial Sciences in Health, Cleveland Clinic Research
Rakhee Banerjee
Department of Microbial Sciences in Health, Cleveland Clinic Research
Vinayak Uppin
Department of Microbial Sciences in Health, Cleveland Clinic Research
Dev Laungani
Department of Microbial Sciences in Health, Cleveland Clinic Research
Grace E. Hamilton
Department of Microbial Sciences in Health, Cleveland Clinic Research
Xiayan Ye
Department of Microbial Sciences in Health, Cleveland Clinic Research
Naseer Sangwan
Center for Microbiome and Human Health, Cleveland Clinic Research
Mohammed Dwidar
Adeline M. Hajjar
Center for Microbiome and Human Health, Cleveland Clinic Research
Belinda Willard
Michael Martin
Cayman Chemical
Erik Guetschow
Cayman Chemical
Patrick Westcott
Cayman Chemical
Megan R. McMullen
Department of Inflammation and Immunity, Cleveland Clinic Research
Laura E. Nagy
Zeneng Wang
Center for Microbiome and Human Health, Cleveland Clinic Research
Stanley L. Hazen
Center for Microbiome and Human Health, Cleveland Clinic Research
J. Mark Brown
Department of Microbial Sciences in Health, Cleveland Clinic Research