Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Wang et al., Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688
Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2
The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection ranges from asymptomatic cases to critical COVID-19 pneumonia. To investigate the role of host genetics...
Mechanics of dust bathing in birds
Dust bathing is a widespread behavior among birds that helps remove ectoparasites, but its mechanical basis remains poorly understood. Here we show that wing flapping during dust bathing generates san...
Lethal toxin–equipped effector cells for the potential treatment of cancer
Lethal toxins could become potent therapies against cancer, but their clinical utility is limited by adverse events upon systemic administration. These could be reduced if the toxins were delivered by...
Condensate-mediated shape transformations of cellular membranes by capillary forces
Phase-separated biomolecular condensates with liquid-like properties play a key role in the organization and compartmentalization of the intracellular environment. Condensate-mediated capillary forces...
High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a Cytosine-Adenosine-Guanine (CAG) repeat expansion in the Huntingtin (...
Correction for Guo et al., A ribosomally synthesized and posttranslationally modified peptide with ADP-ribosylation
Rational quantum mechanics: Testing quantum theory with quantum computers
Motivated in part by John Wheeler’s assertion that the continuum nature of Hilbert Space conceals the “it-from-bit” information-theoretic character of the quantum wavefunction, a theory of quantum phy...
Cannibalism, predation, and refuges of juvenile blue crabs from a 37-year experiment
This 37-y record (1989–2025) of field experiments tested seasonal and annual variation in predation on juvenile blue crabs ( Callinectes sapidus ) in a represen...
Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes
Viruses exploit extracellular vesicles (EVs) to transfer infection-enhancing viral RNAs. However, mechanisms underlying viral RNA loading remain elusive. We leveraged our previous discovery that dengu...
Correction for Chen et al., RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer’s disease
Dislodging the drift barrier: Why do mutation rates vary?
Biosphere expansion drives Earth’s secular oxygenation while tectonics modulate oxygen variability revealed by machine learning
The rise of atmospheric oxygen fundamentally transformed Earth’s surface environment and enabled the evolution of complex life. However, the processes driving long-term oxygen fluctuations remain poor...
Reply to Vankov et al.: Reasoning traces are linked to accuracy and capture key dimensions of problem complexity
Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish
Pharmaco-behavioral screens in scalable in vivo systems have critical advantages for drug discovery relevant to large-effect autism spectrum disorder (ASD) genes. Here, we establish a database and ope...
Underwater cultural heritage and extreme events: Storm impacts under climate change
Extreme weather events cause severe ecological disruptions to the marine environment and socioeconomic impacts, while also endangering the evidences of human history resting underwater. Storms, in par...
Mosaic phenotypic evolution underlies the adaptive success of water-surface colonization in Gerromorpha
Understanding how the remarkable phenotypic diversity observed in organisms arises through shifts in macroevolutionary patterns and tempos is a fundamental challenge in evolutionary biology. Phenotype...
Bert W. O’Malley (1936–2025): A great scientist, mentor, and proud Irishman
Bert W. O’Malley, the “father/grandfather” of the field of molecular endocrinology passed away on November 11, 2025, at the age of 88. In a distinguished career that spanned over 60 years, he probed f...
Creating a responsible authorship culture in science: Anchoring authorship practices in principles of transparency, credit, and accountability
Authorship remains the primary currency of academic credit and a cornerstone of research integrity, yet current practices often fail to reflect the collaborative and interdisciplinary nature of modern...
Global biodiversity and the expanding Tree of Life
Global biodiversity is increasingly threatened, but still poorly known. Preserving higher taxa (e.g., genera, families, orders) is especially important because each higher taxon may represent more gen...
Rapid ice-marginal lake growth in Alaska driven by glacier retreat through bed overdeepenings
The number and cumulative area of ice-marginal lakes have expanded globally in recent decades, with many lakes residing in glacier-bed overdeepenings, which are subglacial basins formed through prefer...
Radiocarbon dating and chemical imaging of carbon black–based Paleolithic cave art in the Dordogne region (France)
Paleolithic parietal art in the Dordogne, Southwestern France, was known to present representations solely made with mineral coloring matters. We found a significant number of carbon black-based figur...
Multifaceted ceramic analysis in the study of political expansion: Insights from the Zhou expansion in Shandong, China
This paper demonstrates the importance of applying multiple analytical methods in ceramic analysis for understanding colonial contact in the past. We examine the Shang–Zhou transition (circa 1000 BCE)...