Proceedings of the National Academy of Sciences
Articles in this Issue
High-quality surrounding landscapes mitigate avian extirpations from forest remnants
The species–area relationship (SAR) has long been used to predict extirpation rates from habitat loss, but these rates depend not only on habitat area but also on the surrounding landscape and species...
Correction for Deridoux et al., Tube feet dynamics drive adaptation in sea star locomotion
On the potential for strategic behavior in jurisdictional REDD+
Given well-known credibility issues in project-based avoided-deforestation credits and over $3 billion in committed credit purchases under ART TREES, the voluntary carbon market is increasingly moving...
Detecting gene–environment interactions to guide personalized intervention: Boosting distributional regression for polygenic scores
Polygenic risk scores can be used to model the individual genetic liability for human traits. Current methods primarily focus on modeling the mean of a phenotype while neglecting the variance. However...
Chronic infection perturbs the affinity hierarchy of antiviral B cells
A key function of the germinal center (GC) reaction consists in the preferential expansion and enrichment of high-affinity B cell clones. Whether and how persistent viral infection thwarts this purpos...
ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice
During spermiogenesis, nuclear remodeling occurs where histones are sequentially replaced by transition proteins (TNPs) and protamines, a process essential for sperm maturation. Although the degradati...
Spirocyclic β-lactone secondary metabolites modulate spliceosome function
Spirocyclic β-lactones (SβLs) are ring-strain activated natural products produced by actinomycetota, possessing potent and selective cytotoxicity, and with an unknown pharmacological mechanism. To fur...
Graph statistics theory of individualized quantitative genetics under haplotype-resolved genome assembly
Quantitative genetics is essential for genetic dissection of complex traits, yet the existing theory fails to illustrate a comprehensive landscape of genetic control mechanisms driving phenotypic vari...
Descent from a common ancestor restricts exploration of protein sequence space
How functional protein sequences are distributed in sequence space is fundamentally important for evolutionary theory and protein design, particularly if a large diversity of protein functions are hid...
Non-ergodicity in ecology and evolution
Stochasticity plays an important role in all biological systems. The standard way to deal with stochasticity involves averaging over an ensemble of independent realizations. However, such mean statist...
Moiré excitons in generalized Wigner crystals
Moiré superlattices of transition-metal dichalcogenide bilayers host strong Coulomb interactions residing in narrow electron bands, leading to correlated insulating states at fractional carrier doping...
Background selection in recombining genomes and its consequences for the maintenance of variation in complex traits
Background selection (BGS)—the reduction of linked neutral diversity via the purging of deleterious mutations—is a pervasive force in genomic evolution. However, its impact on complex phenotypes remai...
Retinol saturase in the mitochondria antagonizes IDH2 and GLUD1 acetylation to mediate heart repair
Facilitating endogenous cardiomyocyte proliferation has emerged as an important strategy for cardiac repair. Conserved retinol saturase (Retsat) functions in producing all-trans 13,14-dihydroretinol i...
Single-molecule dissection of CFTR folding defects and pharmacological rescue
Cystic fibrosis is a lethal genetic disorder caused by misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, most commonly due to the ΔF508 mutation. Despite extensive...
Metabolic trajectories in developing human neocortical neurons
The shift from glycolysis to oxidative phosphorylation is a key step in neural differentiation. Yet, the timing of metabolic rewiring in the development from progenitors to neurons remains elusive, es...
Functional diversity and specialization decoded: Implications for complex particle systems, NeuroAI, and hybrid human–AI ecosystems
Convergence of external and internal stressors on a stress-responsive enhancer of the <i>Sonic hedgehog</i> gene to induce hair disorders
Mammals are constantly exposed to various stressors of internal and external origin. Though hair follicles (HFs) are exquisitely sensitive to stress, it remains largely unknown how stress-induced resp...
Neural circuits for decision-making based on pineal photoreception in zebrafish
Nonmammalian vertebrates possess photosensitive pineal organs. We previously found that in the zebrafish pineal organ, photoreceptor cells expressing parapinopsin 1 (PP1), a bistable opsin, exhibit “c...
WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity in triple-negative breast cancer
Deciphering the mechanisms underlying antitumor immunity is critical for improving cancer immunotherapy efficacy. Here, we identify WFDC21P (lnc-DC) as a positive regulator of antitumor immunity throu...
Jamming as a topological satisfiability transition with contact number hyperuniformity and criticality
The jamming transition between flow and amorphous-solid states exhibits paradoxical properties characterized by hyperuniformity (suppressed spatial fluctuations) and criticality (hyperfluctuations), w...
Proton-activated chloride channel PACC1 as acid sensor in epidermal desquamation
The acidic microenvironment of the stratum corneum is crucial for epidermal desquamation and barrier homeostasis, yet the primary proton sensor that triggers this process remains unknown. Here, we rep...
Model evidence for distinct origins of glacial–interglacial and millennial signals in Greenland dust
Greenland ice-core records show that the mineral dust flux during the last glacial maximum was twenty times greater than present and it responded rapidly during North Atlantic abrupt climate events. B...
Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans
Loss of skeletal muscle mass and strength are common manifestations of frailty in older people and are linked to reduced quality of life. However, whether mitochondria are mechanistically linked to fr...
Divergence of ontogenetic dietary shifts in adaptive radiation
The availability of trophic niches is a key driver of biodiversity, promoting adaptive radiation through evolutionary processes. However, most research has focused on how species adapt to trophic nich...