Proceedings of the National Academy of Sciences
Articles in this Issue
Biomechanical anticoagulation by spherical platelets in extracorporeal systems
Extracorporeal life support, such as hemodialysis, often face the risk of blood coagulation, where systemic anticoagulation with heparin is routinely administered. However, this strategy is contraindi...
Dermcidin has antiviral activity and protects against influenza
Despite the high incidence of influenza virus infections, one-fifth of people infected with influenza remain asymptomatic. The mechanisms associated with this immune resilience are, however, unknown....
How spatial patterns can lead to less resilient ecosystems
Several theoretical models predict that spatial patterning increases ecosystem resilience. However, these predictions rely on simplifying assumptions, such as assuming isotropic and infinitely large e...
Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy
Multiple system atrophy (MSA) is a progressive neurologic disease, known as an α-synucleinopathy. There are currently no effective disease-modifying therapies for MSA. While neuroinflammation is a hal...
Fatty acid regulation of feeding in <i>Caenorhabditis</i> elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system
Regulation of food intake in mammals is complex and controlled by an interplay between hedonic and homeostatic signals, including hormones like leptin, which senses fat storage and suppresses food int...
Temporal neuronal differentiation programs safeguard neuronal diversity
Differentiation programs actively lock neurons into a terminally differentiated state. How differentiation programs operate in distinct neuronal lineages remains obscure. Here, we found that previousl...
Species range shifts often speed ahead of their modeled climatic niches
Anticipating how species distributions will shift with climate change is key for biodiversity conservation and management. Commonly, species’ range shifts are observed by analyzing changes in occurren...
National identity reconfigures brain responses from “them” to “us”
How the human brain flexibly adapts social perception by recategorizing out-group (them) to in-group (us) remains unclear. Using functional MRI in Singapore’s multicultural population, we investigated...
Molecular kinetics dictate population dynamics in CRISPR-based plasmid defense
Understanding and manipulating the spread of mobile genetic elements represents a great challenge with potential benefits across synthetic biology, agriculture, and medicine. A key part of this challe...
“Target species complex” concept: Strengthening environmental risk assessment of engineered gene drives
Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides
Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are structurally diverse natural products that possess a range of bioactivities, often acting as antibiotics, antifungals, or...
Nanoscale infrared spectroscopy reveals complex organic–mineral assemblages in asteroid Bennu
Asteroid Bennu preserves primitive material from the early solar system, and returned samples allow direct examination of how organics and minerals were assembled and altered. We applied nanoscale inf...
Cellular antibody affinity–based CRISPR screening identifies JUNB as a broadly acting antiviral factor
CRISPR screening is a powerful approach to identify genetic perturbations that impact viral infection. However, most virus-focused CRISPR screens utilize selection strategies that limit the ability to...
Regulation of STK38 by autophagy governs YAP1 activity during paligenosis
Paligenosis is a conserved cellular plasticity program that allows mature cells to reenter the cell cycle in response to tissue injury. Paligenosis progresses via three stages: autodegradation (with d...
Versatile SMAD2 and SMAD3 epitope–tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9–SMAD2/3 targets
Transforming growth factor β (TGFβ) signaling pathways are integral for a plethora of biological processes. SMAD2 and SMAD3 are the principal transcriptional effectors of TGFβ superfamily ligands, yet...
Earth’s biodiversity: How much is there?
Projected changes in tropical instability wave activity in the Pacific Ocean under greenhouse warming
Tropical Instability Waves (TIWs) dominate intraseasonal variability in the tropical Pacific Ocean, strongly impacting climate variability and marine ecosystems. However, their response to greenhouse...
Ecological speciation in allopatry is rooted in older divergence
The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus
Hepatitis A virus (HAV) is an unusual picornavirus with two types of extracellular virions: nonenveloped particles (nHAV) shed in feces and quasi-enveloped particles (eHAV) circulating in blood. Both...
Reply to MacColl: Repeated evolution from standing genetic variation
Recent extremes in Antarctic sea ice extent modulated by ocean heat ventilation
Antarctic sea ice extent (SIE) has experienced unprecedented variability in recent decades, with record expansion through 2015, followed by an abrupt transition to sustained decline. Using over two de...
The audience shapes the information content of the honey bee waggle dance
The honey bee waggle dance, which encodes food location, is often thought to involve only one-way information transfer from dancers to signal receivers. Here, we show that the information content of t...
What is quantum biology?
Quantum biology is the field at the intersection of quantum-related physics and the biology of living systems. The goal of the field is to determine if quantum phenomena underpin biological function a...