Proceedings of the National Academy of Sciences
Articles in this Issue
Dual enhancement of superconductivity in FeSe/SrTiO <sub>3</sub> via orbital and correlation synergy
In iron-based superconductors, the d z 2 orbital band typically resides fa...
Integrating trophic importance into conservation of terrestrial vertebrates
There is global consensus on the need to prioritize conservation efforts to prevent biodiversity loss and defaunation. Most current conservation initiatives focus on areas with high species diversity...
The <i>Campylobacter jejuni</i> flagellar V-ring discerns viscosity levels to alter swimming velocity, metabolic gene expression, and fitness
Campylobacter jejuni is an intestinal commensal of birds and animals and a leading cause of bacterial diarrheal disease in humans. In hosts,...
Consecutive catalytic steps of viral RNA polymerase and exonuclease suggest a way to overcome intrinsic nucleotide analogue resistance
Nucleotide analogues (NAs) have been successfully used for the treatment of various RNA virus infections by selectively targeting the viral RNA-dependent RNA polymerase (RdRp) for incorporation into t...
Risk prediction of <i>Helicobacter pylori</i> strains across Correa’s cascade via intelligent analysis of genome-wide SNPs
Only a minority of Helicobacter pylori ( H. pylori...
A polymerase ribozyme increases copying fidelity through pyrophosphate-mediated RNA repair
Prior to the emergence of the contemporary biosphere, the first replicating systems are thought to have progressed through an RNA-based stage. Such an evolving world would likely have transferred heri...
A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes
Cellulose, a primary component of plant cell walls, is synthesized by cellulose synthase complexes (CSCs) at the plasma membrane. Targeting this process with cellulose biosynthesis inhibitors (CBIs) h...
Tuning bubble coalescence rates over orders of magnitude in liquid mixtures of simple surface thermodynamics: Experiments and theory
The coalescence time of bubbles in a liquid depends on the nature of the liquid, which determines both its surface thermodynamics and the molecular interactions between the gas/liquid interfaces, and...
The co-occurrence of ingroup and outgroup prosociality requires cross-group partner choice
An aquaglyceroporin governs cellular water and CO <sub>2</sub> conductance relevant for vesicular mineral formation in a marine calcifier
Many marine organisms generate biominerals by endocytotic uptake of seawater which is modified within calcifying cells to produce an amorphous mineral precursor required to form the mineralized shell...
Active zone plasticity couples sleep need to presynaptic hypophosphorylation
Sleep need is associated with both circuit dynamics and widespread synaptic plasticity, yet the specific synaptic changes underlying sleep homeostasis remain incompletely understood. In...
Madhav Gadgil (1942–2026): A pioneering Indian ecologist’s legacy of biodiversity conservation and human coexistence
Madhav Gadgil was an evolutionary ecologist and champion of governmental and intergovernmental policies for biodiversity conservation, human coexistence with nature, and indigenous rights to land, nat...
Avoidance of MAIT cells is an essential determinant of <i>Listeria</i> monocytogenes pathogenesis
Mucosal-associated invariant T (MAIT) cells are among the most conserved and abundant innate-like T cells in humans that recognize microbial-derived riboflavin precursors and elicit potent antimicrobi...
Cryopreservation through vitrification enables functional recovery of the mouse hippocampus
<i>Arabidopsis</i> YEATS domain proteins facilitate DNA double-strand break repair via homology-directed pathways
DNA double-strand break (DSB) repair is required to maintain genome integrity and organismal fitness. This process occurs within chromatin and although accurate repair requires extensive changes in ch...
A long-distance signaling loop promotes soybean nodulation and productivity
Legume nodulation is initiated when soil bacteria rhizobia infect root hairs and is tightly regulated by host-derived mechanisms that restrict nodule numbers to balance the benefits of symbiotic nitro...
A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow
Thin-strand pericytes cover the deepest reaches of the brain’s capillary network, and their fine processes are intimately associated with adjacent endothelial cells (ECs). Recent work has revealed tha...
Circular and athermal atmospheric CO <sub>2</sub> capture by food waste-derived amyloid sorbents
Food waste contributes substantially to global CO 2 emissions, yet it also offers underutilized opportunities for climate change mitigation within and beyond th...
The Urban Pulse: Diagnosing the urbanization process as spiky, cyclical, and asynchronous
Many urban indicators predominantly focus on static outcomes, failing to capture the dynamic nature of urbanization. Here, we introduce the concept of the Urban Pulse to characterize urbanization as a...
Dysregulation of autophagosome–mitochondria contacts contributes to autophagy dysfunction and neurodegeneration in tauopathy
Mitochondria (Mito) engage in extensive communication with other organelles through membrane contacts. Perturbed mitochondria–organelle interactions are indicated in a variety of neurodegenerative dis...
Functional asymmetry and essential structural roles of PDE6α and PDE6β subunits in rod–photoreceptor integrity
Tetrameric rod phosphodiesterase-6 (PDE6), comprised of an α/β heterodimeric catalytic core and two inhibitory γ subunits, critically regulates cyclic GMP (cGMP) levels in rod photoreceptors. While th...
Targeting the cGAS–STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model
Cyclic GMP–AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), form a key cytosolic DNA-sensing pathway that drives innate immune activation and proinflammatory si...
Reply to Xiao and Imada: Prosociality across group boundaries is possible without partner choice
Structural modeling reveals the mechanism of motor ATPase coordination during type IV pilus retraction
Diverse bacterial species utilize surface appendages called type IV pili (T4P) to interact with their environment. These structures are dynamically extended and retracted from the cell surface, which...
Bridging national climate targets and firm-level decisions: An agent-based model of China’s steel decarbonization pathways
China’s steel sector is pivotal to national and global climate goals, yet decarbonization is constrained by entrenched coal-based processes and regional disparities. Top–down and bottom–up models ofte...