Proceedings of the National Academy of Sciences
Articles in this Issue
mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model
The unyielding antigenic drift of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as the threat of future zoonotic sarbecovirus spillovers, has prompted the search for broadly ne...
Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles
α-synuclein (α-syn) aggregation is a hallmark of synucleinopathies, a class of neurodegenerative disorders such as Parkinson’s disease (PD). Several lines of evidence indicate the involvement of mitoc...
A census of anti-CRISPR proteins reveals AcrIE9 and AcrIE13 as inhibitors of the <i>Escherichia coli</i> K12 type IE CRISPR-Cas system
CRISPR-Cas adaptive immunity systems provide defense against mobile genetic elements and are often countered by diverse anti-CRISPR (Acr) proteins. The type IE CRISPR-Cas of...
Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice
Psychedelic drugs are poised to become mainstream treatments, yet we lack a circuit-level account of how they reshape brain activity. Emerging evidence suggests that multiple psychedelic compounds mod...
Correction for McDonald et al., Can auxiliary indicators improve COVID-19 forecasting and hotspot prediction?
A biomineralized light-guiding structure in the porous calcitic skeleton of the sea star <i>Protoreaster nodosus</i>
Biomineralized structures produced by living organisms are widely recognized for their exceptional mechanical performance, yet their potential optical roles are relatively less explored. Here, we demo...
Correction for Salomon et al., The US COVID-19 Trends and Impact Survey: Continuous real-time measurement of COVID-19 symptoms, risks, protective behaviors, testing, and vaccination
Two-component plant defenses are better than one
Chemical neighborhood exploration for substrate discovery in biocatalysis
Predicting the substrate reactivity strength for a given biocatalyst remains a central challenge in computational biocatalysis. Here, we present Subdate, a modular workflow that combines descriptor-gu...
Regulation of gut epithelial barrier and tuft/goblet cell responses by microbiome repair: Opportunities and future directions
Reply to Wang et al.: Linking microbial metabolites and gut epithelial responses to microbiome-directed therapeutic foods
One target across kingdoms: Chemical inhibition of conserved copper pumps
Programmable DNA hydrogels for dual-mode PD-L1 suppression via polyvalent LYTAC mimics and transcriptional silencing
Immune checkpoint blockade has revolutionized oncology, yet low response rates and acquired resistance—often driven by inadequate Programmed death-ligand 1 (PD-L1) suppression—remain significant barri...
Amazon deforestation reduces precipitation and soybean yields across Southern Brazil
Rapid agricultural expansion has driven forest loss worldwide. Deforestation reduces evaporation, potentially decreasing precipitation and crop yields far beyond agricultural frontiers. Here, we quant...
Shaping chaos in bilayer graphene cavities
Bilayer graphene cavities where electrons are confined within finite graphene flakes provide an alluring platform not only for the future nanoelectronic devices owing to the tunable energy gap but als...
Dissecting hydrogen bond energetics to answer the age-old question: “How much do hydrogen bonds contribute to enzymatic catalysis?”
Enzymes are fundamental to life, providing the rapid reactions and specificity needed to sustain biological processes. While we have overcome the first major challenge in understanding enzymes—identif...
The 2025–2030 Dietary Guidelines for Americans are associated with higher land, water and nitrogen use, and greenhouse gas emissions
Dietary guidelines form the foundation of federal food policy, informing programs such as the Supplemental Nutrition Assistance Program (SNAP), government food procurement, school meals, and military...
Ancient oaks reveal rewilding of Mediterranean forests after the Black Death
In Italy, evergreen holm oaks ( Quercus ilex ) and deciduous sessile oaks ( Quercus petraea ) experienced a synchronized...
New climate regime restructures the ecology of Canada’s Northern Great Lakes
Great Bear Lake (GBL), Great Slave Lake (GSL), and Lake Hazen in northern Canada have recently experienced a shift in fundamental aquatic ecosystem processes associated with accelerated Arctic warming...
Enhanced global storm surges by tropical cyclone poleward migration
Tropical cyclone–induced storm surges pose significant and growing threats to coastal regions; however, their long-term evolution in response to changing tropical cyclone characteristics remains poorl...
Female dolphins use individual vocal labels to track coercive males
Animals rely on identity signaling to navigate social relationships, assess potential mates, and avoid costly interactions. While species- and group-level recognition signals can provide fitness advan...