Proceedings of the National Academy of Sciences
Articles in this Issue
p53 overrides <i>METTL5</i> loss–induced tumor suppression via mitochondrial respiration
The tumor suppressor p53 is pivotal in repressing tumorigenesis under physiological conditions. Paradoxically, we find that wild-type (WT) p53 plays an oncogenic role in relieving...
Enhanced rock weathering has greater promise as a sustainable farming practice than a CO <sub>2</sub> removal technology
Creating common virtual ground: Protocols to democratize open VR research
By immersing participants in consistent virtual environments, VR enhances study realism, reduces confounding variables, and improves procedural control, offering a promising solution for scientists in...
IRE1 regulates the proteostasis of TDP-43/TARDBP in ALS/FTD through ribosome-associated quality control
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative disorders characterized by motor neuron degeneration, leading to muscle weakness, atrophy, and c...
Deviance detection via competitive inhibition between local neocortical ensembles
The process by which neocortical neurons and circuits amplify their response to an unexpected change in stimulus, typically referred to as deviance detection (DD), has traditionally been thought to be...
Skin capillary endothelial cells form a network of spatiotemporally conserved Ca <sup>2+</sup> activity
Ca 2+ signaling and its regulation are important for endothelial cell (EC) function and signaling. Yet, the spatiotemporal organization of Ca...
Unique fingerprint of marine ectotherm body size change during hyperthermal crises
The term “Lilliput Effect” describes a substantial decrease in the average body size of fossil assemblages during major environmental perturbations in Earth’s history, which is reported in many paleon...
MDM2 suppresses c-Myc synthesis by binding to the 5’ mRNA translation regulatory sequence
The p53 tumor suppressor and the c-Myc oncogene are among the most frequently deregulated genes in human cancers, yet the molecular cross talk between these pathways remains poorly understood. MDM2 is...
The origin of spontaneous oxidation in a floating oil nanofilm
Nanoscale geometries can profoundly alter chemical reactivity, yet platforms that isolate and control this regime remain limited primarily to microdroplets. Here, we introduce a simple, surfactant-fre...
Immune cell–intrinsic STING activation drives tumor ferroptosis via AA-mediated suppression of ACSL4 lactylation in colorectal cancer
Ferroptosis has emerged as a key effector mechanism in antitumor immunity, yet the transcellular metabolic cross talk that modulates ferroptotic sensitivity in colorectal cancer (CRC) remains incomple...
Atlantic to Pacific: Outbreak of bivalve transmissible neoplasia detected in hybridizing soft-shell clams and eDNA in Puget Sound
Bivalve transmissible neoplasias (BTNs) are transmissible cancers that have arisen in multiple bivalve species, including Eastern soft-shell clam ( Mya arenaria...
Detecting silent whales using seabed fiber-optic cables
Distributed acoustic sensing (DAS) has emerged as a powerful tool for passive whale monitoring, enabling both the detection of vocalizations and the simultaneous tracking of multiple individuals. Howe...
Cultivation enhances warming sensitivity of redox-driven carbon pulses in black soils: The overlooked role of anaerobic legacy effects
Wetlands on the world’s most fertile black soil serve as critical yet vulnerable carbon reservoirs, yet their stability is threatened by redox fluctuations intensified by climate change and human acti...
A guardian role of TagA in protecting <i>Mycobacterium tuberculosis</i> from nitrosative killing
Upon activation, macrophages generate substantial levels of reactive nitrogen species, which can induce alkylating damage in the DNA of intracellular Mycobacterium tuberculosis...
Counterselection against β-lactamase-expressing bacteria via an activatable photosensitizer that accumulates in resistant pathogens
The rapid global spread of antimicrobial resistance via β-lactamase (bla) demands targeted strategies that selectively eliminate resistant pathogens without exacerbating resistance. Herein, we report...
A broadly conserved gram-positive lipoprotein regulates cell elongation
The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carried out by enzymes that polymerize glycan strands and...
Three centuries of technological innovation: Opportunity is the mother of invention
What socioecological conditions nurture the ingenuity and collaborative interactions underlying transformative technological innovations? We compiled a dataset on more than 400 major technological inv...
Fasting primes small intestinal regeneration after damage via a microbiome–metabolite–chromatin axis
Fasting enhances small intestinal regeneration after radiation, but the contribution of the gut microbiome to this process remains uncharacterized. We identify Akkermansia muciniph...
Protein-enhanced small molecule disruptors of ordered membrane domains
Membrane order and fluidity influence many biological processes. However, tools to manipulate membranes under physiological conditions have been limited. In the process of high-throughput screening fo...
Modeling framework to demonstrate elimination of a vector population: Tsetse elimination in Chad
Every year, over 700,000 people, particularly children under five, die from vector-borne diseases worldwide. Effectively controlling endemics and preventing new outbreaks requires an integrated approa...
Daring few, patient many: Division of labor in decentralized foraging collectives
How can social animals divide labor to forage effectively without a leader? Effective foraging requires balancing individual exploration costs against collective information gains, but without central...
Intracellular delivery of full-length antibodies via organ-targeted lipid nanoparticles
Antibodies are proteins prized for their ability to bind to extracellular antigens with exceptionally high affinities and specificities. These features have motivated researchers to utilize antibody–a...
Natural variation of <i>CTS1</i> confers cold tolerance and blast resistance in rice
Improving multistress resilience in crops is essential for sustainable agriculture, yet the genetic mechanisms coordinating abiotic and biotic stress responses remain poorly understood. This study ide...
Restriction–modification systems are required for <i>Neisseria gonorrhoeae</i> pilin antigenic variation
Neisseria gonorrhoeae (Gc) pilin antigenic variation is a diversity-generating system that uses gene conversion to produce numerous PilE protein variants, the major subunit of the...
Individual differences in speech monitoring: Functional and structural correlates of delayed auditory feedback
Sensory feedback is essential for the fine-tuning of motor actions, and speech production is no exception. It depends on continuous self-monitoring to ensure that produced sounds match intended target...