Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Sinclair et al., Prediction errors disrupt hippocampal representations and update episodic memories
Correction for Nunez et al., Early life-stage thermal resilience is determined by climate-linked regulatory variation
Rat somatic genome editing enables ER+ breast cancer modeling
Genetically engineered mouse models have advanced cancer research, but they fail to mimic some human diseases. Rats offer a powerful alternative for modeling human cancers that are inadequately repres...
Multivalent assembly of PAR-3/aPKC complexes establishes cell polarity in <i>Caenorhabditis elegans</i> zygotes
Cell polarity is essential for the formation and function of animal tissues. Atypical protein kinase C (aPKC), its cofactor PAR-6, and scaffold protein PAR-3 regulate cell polarity in many different a...
Soil water harvest inspired by desert horned lizards, <i>Phrynosoma platyrhinos</i>
Desert environments pose severe water scarcity challenges, leading to unique adaptations among native fauna. Notably, many species of desert horned lizards utilize a dermal drinking method, employing...
Modeling autoimmune encephalitis with the human hippocampus
A receptor kinase complex refines cambium activity in <i>Arabidopsis</i>
In plant development, receptor kinases are often active in disparate cell types, with each requiring vastly different signaling outputs. The ERECTA (ER) receptor kinase and its homologs Erecta-Like1 (...
Allopatric coevolution: Migratory predators may facilitate mimicry between geographically nonoverlapping species
A natural assumption in evolutionary biology is that to coevolve, species must interact with each other and should therefore co-occur. However, many evolutionary dynamics may be mediated by migratory...
High-grade endometrial stromal sarcoma heterogeneity: Fusion-driven, fusion-negative, and related undifferentiated uterine sarcomas
Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma
Mycoelectronics: Bioprinted living fungal bioelectronics for artificial sensation
The intelligence of the human biological system is enabled by the highly distributed sensing receptors on soft skin that can distinguish various stimulations or environmental cues, thus establishing t...