Proceedings of the National Academy of Sciences
Articles in this Issue
High-severity fire now dominant in California forests
Fire severity exerts crucial ecological controls in many forests globally. In California, where annual forest-fire area has increased dramatically in recent decades, understanding how burn severity is...
Hepatitis B virus genome packaging and replication are coordinated by a polymerase-responsive RNA switch in the RNA element epsilon
Hepatitis B virus (HBV), a major human pathogen, replicates its DNA genome by protein-primed reverse transcription of a pregenomic RNA (pgRNA). This process is directed by the pgRNA-borne epsilon (ε)...
Shelf-invading low-oxygen waters control Cenozoic organic carbon burial rates
The thermostatic mechanisms of Earth’s persistent habitability remain unresolved. High-resolution Cenozoic C isotope records, P accumulation, and coarse-fraction I/Ca allow recalculation and assessmen...
Physiology is a hidden dimension of diversity in the radiation of woodland salamanders
Morphological evolution can be explosive, producing visually spectacular adaptive radiations like Caribbean anoles, Malagasy vangas, and African Rift Lake cichlids. Yet morphological stasis, the long-...
Laser ablation microscopy reveals apical notch, apical dominance, and meristem regeneration dynamics in <i>Marchantia polymorpha</i>
Meristems are the growth centers of plants and fundamental in understanding plant development, morphogenesis, and vegetative propagation. Across all plant groups, the phytohormone auxin controls meris...
Transient pores account for cell-penetrating peptide and homeoprotein translocation
Homeoproteins (HPs) and cell-penetrating peptides (CPPs) enter cells by endocytosis and direct membrane crossing (translocation). However, unlike endocytosis, translocation remains globally unknown. H...
Differentiation drives the erosion of positivity on social media
Most people believe that social media discourse is negative and divisive. Here we show how this negativity can evolve even when users are not motivated to be negative. We propose that social media use...
Horseshoe bats foraging in the wild adjust sensing to separate prey echoes from background clutter
How animals handle immense incoming sensory information and regulate sensing is difficult to study under natural conditions. Using miniature GPS tags with microphones we monitored the sensing of freel...
Plant species invasions and community composition processes
Hydrologic connectivity amplifies riverine N <sub>2</sub> O emission hot spots and hot moments across the contiguous United States
Riverine nitrous oxide (N 2 O) emissions constitute a significant yet uncertain component of global greenhouse gas budgets. Integrating approximately 3,600 obse...
SLC11A2 withholds divalent metals from <i>Salmonella</i> in the gut epithelium
There is a constant tug-of-war for transition metals at the pathogen–host interface. Vertebrate hosts modulate the availability of metals to pathogens in a process known as nutritional immunity, but p...
Genomic reconstruction of upland cotton domestication uncovers staged selection, gene flow, and flowering-time adaptation
Upland cotton ( Gossypium hirsutum L.) makes up about 90% of global cotton farming. Despite its importance, the origins and domestication history of upland cott...
Nongenetic engineering nanozyme proximity labeling reveals subcellular in situ interactomes and trafficking pathways of nanoparticles
Elucidating the dynamic interactions between nanocarriers and cellular machinery is critical for advancing targeted nanomedicine. However, the optical microscopy imaging techniques can only provide a...
Record-high Glass coefficient in the shift current response of a ferroelectric halide perovskite
Ferroelectric halide perovskites provide a fertile platform for optoelectronic functions based on the bulk photovoltaic effect, where broken inversion symmetry couples with quantum geometry of wave fu...
Correction for Magaña et al., Not all gut cellular circadian oscillators are food entrainable
Nanoscale regulation of ROS signaling at the plasma membrane tunes the plant response to osmotic stress
The spatiotemporal organization of proteins and lipids within membranes is crucial for ensuring proper cellular signaling. While the segregation of proteins and lipids into membrane nanodomains is wel...
The contingent advantage of photosymbiosis in coral evolution
The ecological success of modern reef-building corals is rooted in photosymbiosis, yet its macroevolutionary benefit remains unclear. Analyzing the Phanerozoic record of inferred zooxanthellate (Z) an...
People prefer to negotiate with women, even when outcomes are identical and gender is unknown
While gender and economic outcomes in negotiation have been studied for decades, much less is known about gender differences in subjective outcomes, such as trust, rapport, and willingness to negotiat...
From molecular motors to chromosome architecture
Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration
The brain’s capacity for integration arises from both its structural wiring and energetically demanding electrochemical signaling. Yet current connectome analyses treat network nodes as functionally h...
Decarboxylative diversification of amino acids and peptides through metallaphotocatalytic editing of acidic residues
Lysine with a characteristic amino group on its side chain is one of the most abundant amino acids in protein structures, making libraries of lysine-based noncanonical amino acids (ncAAs) a valuable r...
Hypoxia-mediated epicardial signaling coordinates coronary angiogenesis and myocardial expansion during zebrafish ventricle maturation
During cardiac development, the myocardium expands in response to physiological demands to achieve proper cardiac morphology and functional contractility, while simultaneously integrating with the dev...
Structural features of the hippocampus covary with memory-guided attention depending on the side of hippocampal sclerosis
Past experiences stored in long-term memory (LTM) provide a valuable resource for making predictions that shape perception and guide goal-directed behavior. Contents from the high-capacity LTM system...