Proceedings of the National Academy of Sciences
Articles in this Issue
CDK8 coordinates jasmonate-induced immunity with sulfur-responsive defense in <i>Arabidopsis</i>
Plant immunity draws heavily on carbon-, nitrogen-, and sulfur-based precursors for the deployment of specialized defense compounds. The jasmonate signaling pathway promotes expression of metabolicall...
Oncogenic snoRNA <i>SNORD78</i> fuels colorectal cancer by protecting the m <sup>6</sup> A reader IMP2 to enhance phospholipid metabolism
Small nucleolar RNAs (snoRNAs) play crucial regulatory roles in various cancers. However, the mechanisms by which snoRNAs regulate N6-methyladenosine (m 6 A) mo...
Disentangling dissociative and nondissociative reaction dynamics in molecular mutual neutralization reactions between CO <sup>+</sup> and O <sup>−</sup>
We have studied the mutual neutralization reaction of CO + with O − at a collision energy of ≤0.1 eV under single-collis...
Quantitative calibration of a spatial QSP model identifies fibroblast impact on HCC immunotherapy
Computational models are increasingly used to predict treatment response and optimize cancer therapeutic strategies. Quantitative systems pharmacology (QSP) models mechanistically simulate tumor progr...
A reassessment of NMDA receptor–dependent presynaptic homeostatic plasticity
Excitatory glutamatergic synapses in the brain are remarkably plastic. Two forms of plasticity have received the most attention: long-term potentiation (LTP) and synaptic homeostasis. While LTP requir...
Dopaminergic neurons preferentially accumulate mtDNA rearrangements
High levels of mitochondrial DNA (mtDNA) deletions have been described in the substantia nigra. However, the mechanisms involved are poorly understood. We found that transient expression of a mitochon...
Many AI analysts, one dataset: Navigating the agentic data science multiverse
Empirical conclusions depend not only on data but also on analytic decisions. Many-analyst studies have quantified this dependence: independent teams testing the same hypothesis on the same dataset re...
Sequential evolution of antidote and toxin links genetic incompatibility with immune responses
Toxin-antidote (TA) systems are selfish genetic elements that ensure their own inheritance by eliminating offspring that do not inherit the module, thereby creating postzygotic genetic incompatibiliti...
A general mobility analysis framework to reveal nonintuitive kinematic characteristics of rigid origami
Rigid origami exhibits intriguing reconfigurability governed by geometric constraints imposed by its creases. This intrinsic relationship gives rise to nonintuitive kinematic characteristics, includin...
Structural basis of membrane engagement and polyreactivity control in HIV-1 MPER broadly neutralizing antibodies
The membrane-proximal external region (MPER) of HIV-1 Env represents a critical target for broadly neutralizing antibodies (bnAbs) due to its conservation and functional importance. However, MPER-targ...
Spatiotemporally controlled matrix softening facilitates deterministic crypt formation in human intestinal organoids
Spatially controlling morphogenesis is a challenge for many organoid systems that manifests as a limited understanding of self-organization of differentiating cells and leads to a high degree of heter...
Raman imaging of the phycosphere reveals sharp gradients of organic matter exuded by single phytoplankton cells
Phytoplankton cells exude a wide array of chemicals in the water column, generating a localized microenvironment known as the phycosphere. Although it is now well accepted that the phycosphere mediate...
APOBEC2 acts as an enforcer of lymphocyte lineage identity
Reply to Sun: Behavior affects epidemic outcomes
Enteroendocrine cells wire the gut–brain vagal axis
The vagal sensory nervous system plays important roles in mediating gut–brain communication and maintaining physiological homeostasis. Although recent research has greatly enhanced our understanding o...
Goal-directed modulation of the default network supports interactions between selective attention, working memory, and prior knowledge
Memory is central to flexible, goal-directed behavior. Prior knowledge shapes our current decisions and future plans and guides our attention to selectively prioritize relevant information in our comp...
Technical sophistication is not evidence
Combined signals of scientific and social consensus best mobilize action on societal challenges even if government and industry oppose
When facing real-world societal challenges, people make decisions about how to act based on multiple, often conflicting messages from various influential stakeholders such as governments, scientists,...
Paintable on-skin dry electrodes with robust skin and device connection for wireless sensing and human–machine interfaces
Reliable and continuous electrophysiological recording is important for health monitoring and human–machine interactions. However, most existing epidermal electrodes suffer from either limited skin–el...
Developmental divergence in voice–reward circuitry differentiates autistic from typically developing children and adolescents
Adolescence is a period of profound social change marked by a developmental shift in attention and motivation from parents toward nonfamilial peers. Autism is a neurodevelopmental condition characteri...
Age-associated epigenetic drift trajectory and cross-national disparities in accelerated aging in domestic dogs
Aging is accompanied by both increasing interindividual heterogeneity and systematic, age-associated alterations in DNA methylation (DNAm). Here, we investigated these complementary dimensions of epig...
Evolutionary innovation through fusion of sequences from across the tree of life
Novel genes arise through multiple mechanisms, including gene duplication, gene fusion, and horizontal gene transfer (HGT). While HGT has increasingly been documented in animals, the posttransfer evol...
Pseudokinase-converting mutation in protein kinase C alpha drives chordoid glioma by pathway rewiring
Chordoid glioma (ChG) is a rare, low-grade brain tumor characterized by a novel recurrent point mutation, D463H, in the kinase domain of protein kinase C alpha (PKCα). The mutation is invariably an As...