Proceedings of the National Academy of Sciences
Articles in this Issue
Crowding controls the scaling of bus frequency with demand
Cities must allocate limited resources to maintain mobility, with uncertainties about the resulting state of the system. Analyzing roughly 3,000 bus routes with more than 4 billion yearly riders acros...
Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning
Adaptive decision-making in dynamic environments requires flexible adjustment of learning speed to balance stability and flexibility. When outcomes are highly stochastic, learners must avoid over-inte...
Inhibitory modulation of age-dependent behavior through <i>dsx</i> -expressing cells in honeybees
Social insects exhibit distinct age-dependent behavioral repertoires that collectively contribute to the common benefits of a colony. However, how the nervous system manifests the capacity of such age...
Experimental drought drives divergent succession of soil microbiota
As droughts become increasingly severe and prolonged worldwide, understanding how belowground biodiversity changes over time under water limitation is critical for assessing ecosystem resilience. Howe...
Uninterrupted optical resolution of identical point scatterers undergoing nanometric changes in distance
In established superresolution fluorescence microscopy or nanoscopy, resolving identical fluorescent molecules at subdiffraction distances requires the molecules to emit sequentially so that they brie...
Finding Turing islands through dynamical exploration
Internal stress controls tendril writhing dynamics in climbing plants
We present experimental results on the writhing dynamics of cucumber plant tendrils subjected to an axial traction force. At low forces, the tendrils’ curvature saturates exponentially in time at a li...
Reading taste in a bee’s face
Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase
The biogenesis of multipass membrane proteins challenges the endoplasmic reticulum (ER) quality control, particularly when transmembrane segments contain polar or charged residues required for functio...
Zero-deforestation commitments in Indonesia’s palm oil sector achieve high compliance but no additionality
In response to public pressure, companies have increasingly adopted voluntary sustainable sourcing commitments. Yet, it often remains unclear whether such commitments lead only to the narrow goal of s...
CD64 enables TCR-dependent, MHC-independent CTL cytotoxicity of AML cells
CD8+ T cell–mediated cytotoxicity classically occurs through engagement of an alpha-beta T cell receptor (TCRαβ) with a peptide–class I major histocompatibility complex (pMHC). However, it is also kno...
The geometry of vision, set in motion
HDA19-mediated deacetylation of histone H3.3 at lysines 27 and 36 regulates plant sensitivity to salt stress
Plants survive extreme environments through rapid chromatin reprogramming, yet the epigenetic marks that confer stress resilience remain poorly understood. Histone deacetylase HDA19 is a key epigeneti...
<i>Fusarium oxysporum</i> –induced ABA signaling triggers root vascular remodeling for plant defense
Root vascular pathogens like Fusarium oxysporum (Fo) severely impact agriculture by colonizing the xylem, thereby disrupting the transport of water, nutrients,...