Proceedings of the National Academy of Sciences
Articles in this Issue
Microscopic basis of reaction center modulation in PsbA variants of photosystem II
Photosystem II (PSII) is a protein–pigment complex that utilizes sunlight to catalyze water oxidation and plastoquinone reduction, initiating the electron transfer (ET) cascade in oxygenic photosynthe...
Material-to-system tailored multilayer-cyclic strategy toward practical atmospheric water harvesting
Solar-driven atmospheric water harvesting (AWH) presents a sustainable approach for freshwater production with sunlight as the sole energy input. To address challenges posed by diurnal moisture variat...
Cardiac signals inform auditory regularity processing in the absence of consciousness
In healthy awake individuals, the neural processing of bodily signals is not only essential for survival but can also influence perception and compete with external stimulus processing. Yet, the mecha...
How infants look shapes what they learn
Brillouin super-cooling/heating in a non-Hermitian phononic dimer
The ability to coherently manipulate phonons through light permits cooling and heating microscale quantum systems for various critical fields in metrology, information processing, and sensing. However...
Strategic campaign attention to abortion before and after <i>Dobbs</i>
In 2022, the US Supreme Court overturned the constitutional protection of abortion rights established in Roe v. Wade . In doing so, Dobbs v....
Cyclization of archaeal membrane lipids impacts membrane protein activity and archaellum formation
Enhancement of the cyclization of membrane lipids GDGTs (glycerol dialkyl glycerol tetraethers) is a critical strategy for archaea to adapt to various environmental stresses. However, the physiologica...
A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain
Scheduled surgeries elicit stress in many patients. Levels of preoperative stress, anxiety, and female gender are known risk factors for increased and prolonged postoperative pain. The mechanisms by w...
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
MEX-5 regulates the formation and dissolution of P granules in Caenorhabditis elegans embryos, yet the thermodynamic basis of its activity remains unclear. Here...
Identifying intermolecular interactions in single-molecule localization microscopy
Intermolecular interactions underlie all cellular functions, yet visualizing these interactions at the single-molecule level remains challenging. Single-molecule localization microscopy (SMLM) offers...
Estrogen-related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions
Mitochondrial energy metabolism is vital for muscle function and is tightly controlled at the transcriptional level, both in the basal state and during adaptive muscle remodeling. The importance of th...
Everyday challenges to women’s presence and authority yield greater burnout and less persistence in a male-dominated profession
While most people believe that women (vs. men) experience more discriminatory treatment at work, especially in male-dominated professions, relatively few women report experiencing such treatment thems...
Tool use aids prey-fishing in a specialist predator of stingless bees
Tool use is widely reported across a broad range of the animal kingdom, yet comprehensive empirical tests of its function and evolutionary drivers remain scarce, predominantly focused on a few relativ...
Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processes
Intercalated cells (ICs) in the mammalian kidney regulate circulatory pH through IC subtype–restricted actions of bicarbonate transporters: pH is elevated by Slc4a1 restricted to type A-ICs (A-ICs) an...
Aerobic nitrogen cycle 100 My before permanent atmospheric oxygenation
The Great Oxidation Event (GOE) represents a major shift in Earth’s surficial redox balance. Delineating the driver(s) and tempo of the GOE and its impact on microbial evolution and biogeochemistry ca...
RNA sequencing analysis of viromes of <i>Aedes albopictus</i> and <i>Aedes vexans</i> collected from NEON sites
Climate change is significantly impacting the geographic range of many animal species and their associated microorganisms, hence influencing emergence of vector-borne diseases. Mosquito-borne viruses...
Reply to Royka and Santos: Representing ignorance, and the evolution of theory of mind
Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability
Informing does not require attributing ignorance
MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4
Group traits moderate the relationship between individual social traits and fitness in gorillas
Evidence across a broad range of disciplines has demonstrated how individuals’ social environments can impact their health, lifespan, reproduction, and ultimately their evolutionary fitness. Past rese...
Ecosystem relocation on Snowball Earth: Polar−alpine ancestry of the extant surface biosphere?
Geological observations informed by climate dynamics imply that the oceans were 99.9% covered by light-blocking ice shelves during two discrete, self-reversing Snowball Earth epochs spanning a combine...
Quadruple adenine base–edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease–engineered T cells
Genome-editing technologies have enabled the clinical development of allogeneic cellular therapies, yet the optimal gene-editing modality for multiplex editing of therapeutic T cell product manufactur...
The fate of South America’s endemic mammalian fauna in response to the most dramatic Cenozoic climate disruption
Around 34 Mya, the Eocene−Oligocene transition (EOT) marked the most dramatic global climatic cooling of the Cenozoic. On a planetary scale, paleontological evidence suggests that this transition was...
A half-century of climate change in major agricultural regions: Trends, impacts, and surprises
Efforts to anticipate and adapt to future climate can benefit from historical experiences. We examine agroclimatic conditions over the past 50 y for five major crops around the world. Most regions exp...