Proceedings of the National Academy of Sciences
Articles in this Issue
Shared host genetic landscape of respiratory viral infection
Respiratory viruses represent a major global health burden. Although these viruses have different life cycles, they may depend on common host genetic factors, which could be targeted by broad-spectrum...
Behavioral sequences across multiple animal species in the wild share common structural features
Animal behavior can be decomposed into a sequence of discrete activity bouts over time. Analyzing the statistical structure of such behavioral sequences can provide insights into the drivers of behavi...
A combined experimental and computational analysis of mantATP turnover in skinned muscle fibers
Myosin is the primary motor protein in skeletal muscle, responsible for adenosine triphosphate (ATP) hydrolysis that drives muscle contraction. In addition to force production, resting myosin consumes...
Foraging for water by MIZ1-mediated antagonism between root gravitropism and hydrotropism
Root system integrates multiple environmental cues, chiefly gravity and soil humidity, to anchor plants in soil and forage for water. While the mechanism of auxin-mediated root gravitropism is compara...
Transcriptomic and proteomic ramifications of segmental amplification in <i>Escherichia coli</i>
Gene amplification can drive adaptation by rapidly increasing the cellular dosage of critical gene products. Segmental amplifications often encompass large genomic regions surrounding the gene(s) unde...
Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening
Schnyder corneal dystrophy (SCD) is a rare autosomal dominant condition characterized by the opacification of the cornea owing to the abnormal deposition of cholesterol. SCD-associated mutations have...
Acoustic percolation switches enable targeted drug delivery controlled by diagnostic ultrasound
Delivering biomedicines to specific sites of disease using remote-controlled devices is a long-standing vision in biomedical research. However, most existing externally triggered delivery systems are...
Structure and evolution of photosystem I in the early-branching cyanobacterium <i>Anthocerotibacter panamensis</i>
Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving organisms capable of oxygenic photosynthesis. However, and until recently, photosynthesis studies in thylakoid-f...
Discovery of an LSD1 PROTAC degrader
Aberrant expression of lysine-specific demethylase 1 (LSD1) has been implicated in various cancers, including acute myeloid leukemia (AML). Recent studies have revealed both catalytic and noncatalytic...
Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging
New immunosenescence targets for preventing senescence-associated pathological cardiac hypertrophy (SA-PCH) need to be explored. In the present study, with physiologically aged human and mouse samples...
Diversity statistics of onomastic data reveal social patterns in Hebrew Kingdoms of the Iron Age
The distribution of personal names provides unique, yet often overlooked, insight into modern and historical societies. This study employs diversity statistics—commonly used in ecology—to analyze onom...
Kernels of selfhood: GPT-4o shows humanlike patterns of cognitive dissonance moderated by free choice
Large language models (LLMs) show emergent patterns that mimic human cognition. We explore whether they also mirror other, less deliberative human psychological processes. Drawing upon classical theor...
Unraveling structural transitions and kinetics along the fold-switching pathway of the RfaH C-terminal domain using exchange-based NMR
The bacterial transcriptional regulator RfaH comprises structurally and functionally distinct N- (NTD) and C- (CTD) terminal domains. The latter switches from a helical hairpin packed against the NTD...
Exact and efficient phylodynamic simulation from arbitrarily large populations
Many biological studies involve inferring the evolutionary history of a sample of individuals from a large population and interpreting the reconstructed tree. Such an ascertained tree typically repres...
Structural basis of human Na <sub>v</sub> 1.5 gating mechanisms
Voltage-gated Na v 1.5 channels are central to the generation and propagation of cardiac action potentials. Aberrations in their function are associated with a...
Electric field–induced pore constriction in the human K <sub>v</sub> 2.1 channel
Gating in voltage-dependent ion channels is regulated by the transmembrane voltage. This form of regulation is enabled by voltage-sensing domains (VSDs) that respond to transmembrane voltage differenc...
Structural insights into the activation of the human prostaglandin E <sub>2</sub> receptor EP1 subtype by prostaglandin E <sub>2</sub>
Prostaglandin E 2 (PGE 2 ) mediates diverse physiological processes through four G protein–coupled receptor subtypes (EP...
Risk-aware electricity dispatch with large-scale distributed renewable integration under climate extremes
Distribution networks, with large-scale integration of distributed renewable resources, particularly rooftop solar photovoltaic systems, represent the most extensive yet vulnerable components of moder...
Interpreting dynamic-compression experiments to uncover the time dependence of freezing: Application to gallium
Using pulsed-power magnetic field sources to compress gallium to gigapascal pressures on nanosecond timescales, we report here experiments on shockless dynamic compression of a liquid metal. Time-reso...
Visualization and quantification of local concentration gradients in evaporating water/glycerol droplets with micrometer resolution
Evaporation of sessile multicomponent droplets is ubiquitous in many common processes, such as printing, cooling, and coating. The evaporation rate is not evenly distributed across the surface of the...
QnAs with Thomas A. Henzinger
Basement membrane patterning by spatial deployment of a secretion-regulating protease
While paradigms for patterning of cell fates in development are well established, paradigms for patterning morphogenesis, particularly when organ shape is influenced by the extracellular matrix (ECM),...
<i>Staphylococcus aureus</i> SaeR/S-regulated factors overcome human complement–mediated inhibition of aggregation to evade neutrophil killing
Staphylococcus aureus ( S. aureus ) is a frequent culprit in implant-associated infections and employs many virulence factors to escape kill...
Global patterns of nutrient limitation in soil microorganisms
The availability of nitrogen (N) and phosphorus (P) is essential for soil microbial activity and growth, yet global patterns of N and P limitation in soil microbial metabolism remain largely unknown....
Characterizing the concentration and load dependence of phosphate binding to rabbit fast skeletal actomyosin
Intensely contracting fast skeletal muscle rapidly loses the ability to generate force, due in part to the accumulation of phosphate (P i ) inhibiting myosin’s...