Proceedings of the National Academy of Sciences
Articles in this Issue
The fetal hydrops–associated single-residue mutation L322P disrupts mechanical but not chemical activation of the PIEZO1 ion channel
The mechanically activated PIEZO1 ion channel is genetically linked to numerous physiological and pathophysiological processes. For example, deleting PIEZO1 in...
Trends in coastal storm impacts are not only about changes in hurricanes
Biochar in the circular bionutrient economy
The circular bionutrient economy is defined here as the circular economy of nutrients in managed organic residues. Here, we posit that biochar technology can stimulate the circular bionutrient economy...
Targeted deletions of large syntenic regions in <i>Arabidopsis thaliana</i>
Plant genomes have undergone multiple rounds of whole-genome duplication (WGD) throughout their evolutionary history. As a result, many species, including Arabidopsis thaliana...
A stochastic theory of urban metabolism
A current tenet in the science of cities is the emergence of power-law relations between population size and a variety of urban indicators, echoing allometric scaling in living organisms akin to Kleib...
Climate change and <i>Vibrio</i> : Environmental determinants for predictive risk assessment
Climate change significantly impacts the incidence and abundance of microorganisms, including those essential for environmental cycles and those pathogenic to humans and animals. Shifts in conditions...
Three decades of declines restructure butterfly communities in the Midwestern United States
Insects are declining worldwide. These declines have been documented across taxonomic groups and are worrisome given ecosystem services provided by insects. Long-term data have illuminated butterfly d...
Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality
Metatranscriptomic data from a mass-mortality event of adult Pacific Oysters, Crassostrea ( Magallana )...
Mesozoic atmospheric CO <sub>2</sub> concentrations reconstructed from dinosaur tooth enamel
Air-breathing vertebrates incorporate a fraction of isotopically anomalous air O 2 in their body water. The 17 O isotope...
The edge-averaging process on graphs with random initial opinions
In several settings (e.g., sensor networks and social networks), nodes of a graph are equipped with initial opinions, and the goal is to estimate the average of these opinions using local operations....
Scalable high-voltage Zn||MnO <sub>2</sub> batteries achieved by mild amphiphilic hydrogel electrolytes
The practical applications of aqueous Zn||MnO 2 batteries are limited by their small areal capacity, low discharging plateau, and clumsy packing device. Current...
TRIM24 as a therapeutic target in endocrine treatment–resistant breast cancer
While Estrogen receptor alpha (ERα)+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since ERα is still the main driver in most therapy-resistant tumors, al...
Structural basis and affinity improvement for an ATP-binding DNA aptamer
DNA aptamers that bind small molecules with high affinity have revolutionized the fields of biosensing and bioimaging. Recently, a DNA aptamer named 1301b has been identified as the most potent DNA ap...
A 65-kb deletion survey identifies a distal <i>cis-</i> regulatory region for red-light induction of <i>Ghd7</i> , a key rice floral repressor
The Ghd7 ( Grain number, plant height, and heading date 7 ) gene integrates red light signals and circadian rhythms to c...
Therapeutic CD8 <sup>+</sup> T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound
A primary obstacle for HIV elimination is the long-term viral reservoir in lymphoid tissues (LT) that can cause rebound viremia if therapy is stopped. Cytotoxic CD8 +...
Observed declines in leaf nitrogen explained by photosynthetic acclimation to CO <sub>2</sub>
Widespread evidence of decreasing leaf nutrients has raised concerns about ecosystem productivity under global change. Interpreting trends in leaf nutrients has important implications for the fate of...
TRPC4 regulates limbic behavior and neuronal development by stabilizing dendrite branches through actomyosin-driven integrin activation
Transient Receptor Potential Canonical 4 (TRPC4) channels have been implicated in multiple neurological functions, including anxiety and sociability. TRPC4 variants were also found in patients with au...
Ludwig–Soret microscopy with the vibrational photothermal effect
Vibrational microscopy provides label-free, bond-selective chemical contrast by detecting molecular vibrations, making it invaluable for biomedical research. While conventional methods rely on the dir...
Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes
Glucose transporters (GLUT1/2) facilitate glucose uptake in pancreatic β cells, triggering insulin secretion. The availability of GLUTs at the plasma membrane (PM) is governed by its expression, deliv...
Embolism resistance supports the contribution of dry-season precipitation to transpiration in eastern Amazon forests
Transpiration drives most of the local rainfall during the dry season in the Amazon forests by recycling moisture into the atmosphere. However, the source, temporal origin of transpiration, and spatia...
Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors
GluA2 is a key subunit of α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) ion channels that is abundantly expressed in the vertebrate bra...
Keldysh tuning of photoluminescence in a lead halide perovskite crystal
In 1964, Keldysh laid the groundwork for strong-field physics in atomic, molecular, and solid-state systems by delineating a ubiquitous transition from multiphoton absorption to classical field-driven...
Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice
Non–rapid eye movement (NREM) sleep facilitates memory consolidation by transferring information from the hippocampus to the neocortex. This transfer is thought to occur primarily when hippocampal sha...
Stress granule–mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging
Male infertility remains a major unmet medical challenge, with poorly defined molecular mechanisms and no effective therapies. Here, we identify a stress granule–mediated necroptotic pathway as a key...
Solution spillover: Pairing issues with ideological solutions fuels polarization
Recent research has focused on understanding ideological and affective political polarization in the United States; however, the polarization of issue salience—defined as personal beliefs about how im...