Proceedings of the National Academy of Sciences
Articles in this Issue
Correction to Supporting Information for Rei et al., Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway
Correction for Ota et al., Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling
Repeated polyploidization shapes divergence in floral morphology in <i>Lithophragma bolanderi</i> (Saxifragaceae)
Polyploidization is an important driver of evolution and diversification in flowering plants. Here, we assess how repeated polyploidization may have shaped diversification of floral morphology in...
Ensemble approaches for short-term dengue fever forecasts: A global evaluation study
Dengue fever, a tropical vector-borne disease, is a leading cause of hospitalization and death in many parts of the world, especially in Asia and Latin America. Where timely dengue surveillance exists...
A critical role for <i>Vibrio parahaemolyticus</i> LPS to mediate evasion of host immune response during infection
Vibrio parahaemolyticus ( V. para ), a Gram-negative halophilic bacterium, is the leading cause of seafood-borne gastroenteritis. While the...
Locusts employ neuronal sensory prioritization to reconcile two conflicting olfactory signals while aggregating
Migratory locusts ( Locusta migratoria ) emit two key odorants during aggregation: 4-vinylanisole (4VA), which serves as an aggregation pheromone attracting con...
Mechanistic insights into the small-molecule inhibition of influenza A virus entry
Influenza A virus (IAV) is a zoonotic pathogen responsible for seasonal and pandemic flu. The extensive genetic and antigenic diversity within and between IAV phylogenetic groups presents major challe...
Our current climate already merits serious research and policy attention
DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons
Somatic mutations in cortical neurons have been implicated in psychiatric disorders. While endogenous DNA damage and repair errors are potential contributors to these mutations during development, the...
Correction for Jeong et al., Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis
Étienne-Émile Baulieu (1926–2025): Scientist of steroids and champion of women’s reproductive rights
Having trained as a physician, Étienne-Émile Baulieu soon turned his focus to research, as early as his medical internship. He went on to make major contributions on ketosteroids and other steroids, s...
Plant-specific mitochondrial fission machinery connects mitochondrial dynamics and mitophagosome formation for piecemeal mitophagy
As the energy center of the cell, mitochondria display enormous metabolic plasticity to meet the cellular demand for plant growth and development, which is tightly linked to their structural and dynam...
Geographical diversity of peer reviewers shapes author success
Scientific institutions like funding agencies and journals rely on peer reviewers to select among competing submissions. How does the geographical diversity of reviewers affect which authors are selec...
Analytical solutions for light propagation of LED
Analytical solutions of diffusion theory for light propagation in turbid media are essential for optical diagnostics and therapeutic applications, including cerebral oximetry, hemodynamic monitoring,...
Correction for Kuo et al., A proteomic signature of healthspan
Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases
The meninges serve as a critical interface between the peripheral immune system and the central nervous system, playing a crucial role in maintaining parenchymal homeostasis. Neurodegenerative disorde...
Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients
Sweat parameters such as volume and chloride concentration may offer invaluable clinical insights for people with CF (PwCF). Pilocarpine-induced sweat collection for chloridometry measurement is the g...
Anyon superconductivity from topological criticality in a Hofstadter–Hubbard model
We argue that the combination of strong repulsive interactions and high magnetic fields can generate electron pairing and superconductivity. Inspired by the large lattice constants of moiré materials,...
Blood–labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus
Hearing loss (HL) in patients with systemic lupus erythematosus (SLE) has been widely reported, though the underlying mechanisms remain unclear. In this study, we demonstrate significant HL in an imiq...