Blood
Articles in this Issue
Impact of low disease burden on the safety and efficacy of BCMA CAR-T in patients with Relapsed/Refractory multiple myeloma
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapies targeting B-cell maturation antigen (BCMA) have...
Venetolax plus azacitidine is effective maintenance therapy after allogeneic hematopoietic stem cell transplantation in patients with intermediate/high-risk Acute Myeloid Leukemia
Abstract Background: Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with intermediate/high-risk ac...
Adding eltrombopag to immunosuppressive treatment with cyclosporine as front-line therapy for moderate aplastic anemia improves trilineage hematologic response: One-year analysis of the randomised, placebo-controlled, double-blind Phase III trial eltrombopag for moderate aplastic anemia (EMAA Trial)
Abstract Introduction: Eltrombopag (EPAG) combined with horse antithymocyte globulin and cyclosporine A (CSA) when given as first-line treat...
Real world outcomes in patients with acquired thrombotic thrombocytopenic purpura (TTP) treated with caplacizumab
Abstract BACKGROUND Acquired Thrombotic thrombocytopenic purpura (TTP) is characterized by fever, microangiopathic hemolytic anemia, thromboc...
Transfusion dosing targets; Concentration vs potency (a case for oxygen delivery-based metrics)
Abstract INTRODUCTION: Blood transfusions are used to treat anemia when oxygen (O2) delivery to tissues is compromised or when the body's co...
Outcome of adult B-precursor acute lymphoblastic leukemia (ALL) treated with blinatumomab in addition to chemotherapy independent of MRD: First results from the national GMALL registry
Abstract The German Multicenter Study Group for Adult ALL (GMALL) has maintained a prospective national registry (NCT02872987) since 2009, e...
Pre-treatment vaccine seroprotection is markedly lower in BCMA-CAR vs CD19-CAR recipients with limited post-therapy modulation
Abstract Introduction:Infections are the leading cause of non-relapse mortality in patients (pts) treated with chimeric antigen receptor T c...
Efficacy and safety of zanubrutinib-containing regimens in patients with newly diagnosed Mantle Cell Lymphoma: Interim results from a Phase II investigator-initiated study
Abstract Background: First-line treatments such as intensive immunochemotherapy followed by autologous stem cell transplantation (ASCT) prov...
Real-world temporal evaluation of static risk prediction in polycythemia vera
Abstract Current prognostic models for polycythemia vera (PV)—including ELN (Barbui et al. Leukemia, 2018), MIPSS-PV (Tefferi et al. Br J Ha...
XPO1 inhibitor WJ01024 monotherapy or in combination with ruxolitinib in myelofibrosis
Abstract Introduction Ruxolitinib is a common first-line therapy in myelofibrosis (MF), reducing spleen size and alleviating symptoms. Howeve...
RNA fusion sequencing identifies clinically relevant and novel fusions with therapeutic implications in adults with Acute Myeloid Leukemia (AML)
Abstract Background: Current risk stratification of AML is based on the presence or absence of specific cytogenetic abnormalities and somati...
Reduced intensity haploidentical bone marrow transplantation in children with severe sickle cell disease (SCD): BMT CTN 1507
Abstract Background: Allogeneic hematopoietic stem-cell transplantation has curative potential for sickle cell disease (SCD). Event-free sur...
Long-term outcomes of allogeneic stem cell transplantation in β-thalassemia major: A single centre experience from Algeria
Abstract Introduction: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for children with...
Causes of death in DDX41-mutated myeloid neoplasms: A retrospective study
Abstract Introduction: The DEAD-box helicase 41 (DDX41) gene, located on chromosome 5q35, is a tumor suppressor gene involved in RNA process...
Safety and efficacy of consolidation-Phase blinatumomab in newly diagnosed B-cell acute lymphoblastic leukemia : A systematic review and meta-analysis
Abstract Background: B-cell acute lymphoblastic leukemia (B-ALL) accounts for 0.3% of all new cancer cases and 0.2% of cancer-related deaths...
Trends in muscle and fat metrics and their association with outcomes following CAR T-cell therapy in older adults with non Hodgkin lymphoma.
Abstract Chimeric Antigen Receptor (CAR-T) therapy has transformed treatment for non-Hodgkin lymphoma (NHL) and is now standard as early as...
Fludarabine pharmacokinetic model identifies an optimal exposure associated with improved outcomes in allogeneic hematopoietic cell transplantation recipients receiving post-transplant cyclophosphamide
Abstract Background: Fludarabine (Flu) is a key conditioning agent to induce host lymphopenia and prevent rejection prior to allogeneic hema...
Age-stratified prognostic performance of patient- vs disease-related IPI factors in large B-cell lymphoma
Abstract Introduction The International Prognostic Index (IPI, NEJM, 1993) has guided risk stratification in large B-cell lymphoma (LBCL) fo...
Multi-center real world analysis of treatment outcomes of non-COVALENT btki, pirtobrutinib, in patients with COVALENT btki relapsed/refracdtory Mantle Cell Lymphoma
Abstract Introduction: cBTKi have made a substantial impact in pts w/ MCL, but pts who develop PD while on treatment w/ cBTKi have historica...
A dual targeting BCMA and CD19 fastcar-t (GC012F/AZD0120) as first-line therapy for newly diagnosed multiple myeloma
Abstract Background GC012F/AZD0120 is an autologous CAR-T therapy that targets both B cell maturation antigen (BCMA) and CD19. It is develop...
Trends and disparities in ischemic heart disease and anemia-related mortality in adults aged ≥ 65 years in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Ischemic heart disease and anemia are prevalent in older adults in the United States and, when concomitant, significa...
Idiotype mRNA therapeutic vaccination in a mouse model of B cell lymphoma
Abstract B cell lymphoma is a clonal disease where each tumor cell expresses the same, unique variable region sequence that makes up the B c...
Pediatric sickle cell outpatient pain management: A quality improvement initiative
Abstract Background: Primary Children's Hospital (PCH) is a 289-bed tertiary care children's teaching hospital in Utah, caring for approxima...
Changing burden of Acute Myeloid Leukemia in the United States: A 23-year national analysis
Abstract Introduction: Acute Myeloid Leukemia (AML) remains a clinically and biologically aggressive hematologic malignancy with substantial...
Iron overload disrupts alveolar-capillary tight junctions via oxidative stress in a murine model
Abstract Introduction：Iron overload is a common complication in hematologic diseases. While its toxic effects on the heart, liver, and panc...