Blood
Articles in this Issue
Recycling is “bad to the bone” in patients with myeloma
Non-V600E <i>BRAF</i> mutations and treatment for hairy cell leukemia
Abstract We found 20 patients with an immunophenotype consistent with classic hairy cell leukemia and BRAF mutations other than just V600E. Fourteen had 1 non-V600E BRAF mutation and...
17(<i>R</i>)-Resolvin D1 protects against sickle cell–related inflammatory cardiomyopathy in humanized mice
Abstract Cardiovascular disease has been recognized as the main cause of death in adults with sickle cell disease (SCD). Although the exact mechanism linking SCD to cardiomyopathy re...
Seeing is believing: a histology textbook’s dream case of sarcoidosis
CAR T cells in autoimmunity: game changer or stepping stone?
Abstract The advent of chimeric antigen receptor (CAR) T cells has revolutionized the treatment landscape for hematologic malignancies, and emerging evidence suggests their potential...
Prognostic and therapeutic implications of measurable residual disease levels during remission induction of childhood ALL
Abstract We evaluated the prognostic and therapeutic significance of measurable residual disease (MRD) during remission induction in pediatric patients with acute lymphoblastic leuke...
Emerging biomarkers for CD3×CD20 bispecific antibodies in lymphoma
Abstract Novel CD3×CD20 bispecific antibody (BsAb) immunotherapies have entered the armamentarium for follicular lymphoma and diffuse large B-cell lymphoma based on accelerated appro...
Targeting <i>Enterobacter cloacae</i> attenuates osteolysis by reducing ammonium in multiple myeloma
Abstract Multiple myeloma (MM)-induced bone disease affects not only patients’ quality of life but also their overall survival. Our previous work demonstrated that the gut microbiome...
Methotrexate and glucarpidase: the emperor has new clothes
Common hereditary variants of the <i>APOE</i> gene and posttransplant outcome in acute myeloid leukemia
Abstract Apolipoprotein E (APOE) has multiple functions in metabolism and immunoregulation. Its common germ line variants APOE2, APOE3, and APOE4 give rise to 3 functionally distinct...
Functional assessment of genetic variants in thrombomodulin detected in patients with bleeding and thrombosis
Abstract Thrombomodulin (TM) expressed on endothelial cells regulates coagulation. Specific nonsense variants in the TM gene, THBD, result in high soluble TM levels causing rare blee...
Glucarpidase for treatment of high-dose methotrexate toxicity
Abstract High-dose methotrexate (MTX) results in high rates of acute kidney injury (AKI), neutropenia, and hepatotoxicity. Glucarpidase is a recombinant enzyme that cleaves MTX, but...
PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells
Abstract Differentiation arrest and dependence on oxidative metabolism are features shared among genetically diverse acute myeloid leukemias (AMLs). A phenotypic CRISPR-CRISPR–associ...
Thrombophilic thrombomodulin variants
STINGing leukemia stem cells through PSTK inhibition
17(<i>R</i>)-Resolvin D1: a novel approach for SCD cardiomyopathy
Venetoclax plus daunorubicin and cytarabine for newly diagnosed acute myeloid leukemia: results of a phase 1b study
Abstract Venetoclax (Ven), when combined with intensive chemotherapy, shows promise for untreated acute myeloid leukemia (AML), but its integration with the 7+3 regimen remains under...